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Momcilovic et al., J Biol Chem 2006
:
Finally, expression of TAK1 and TAB1 in HeLa cells or treatment of cells with cytokines stimulated phosphorylation of Thr-172 of AMPK Lee et al., Bone 2010
(Bone Resorption) :
AMPK negatively regulates RANKL, possibly by acting through CaMKK and TAK1 Chen et al., Mol Cell Biochem 2013
:
TAK1 inhibitor significantly suppressed H2O2 induced AMPK activation and following cardiomyocyte death, while over-expression of TAK1 facilitated AMPK activation and aggregated cardiomyocyte death