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BCL2 — IL15
Text-mined interactions from Literome
Chang et al., Yonsei Med J 2000
(HIV Infections) :
The results were as follows : 1 ) IL-15 reduced culture induced lymphocyte apoptosis in HIV patients in a dose dependent manner, and reached a plateau level at a concentration of 100 ng/ml ; 2 ) IL-15 significantly reduced the level of apoptosis after 3 days ( 14 % ) and 5 days ( 15 % ) of culture in HIV patients, while no difference was observed in HIV ( - ) donors ; 3 ) The percentage of viable cells among the total number of lymphocytes was significantly enhanced by 25 % in HIV patients with IL-15 ; 4 )
Bcl-2 expression was decreased in HIV patients ( 53.9 +/- 12.3 % ) compared to HIV ( - ) donors ( 93.0 +/- 3.7 % ), and
IL-15 increased Bcl-2 expression by 21.2 +/- 5.2 % in HIV patients ; 5 ) Fas expression was increased in HIV patients ( 70.2 +/- 4.6 % ) compared to HIV ( - ) donors ( 32.4 +/- 4.3 % ), and IL-15 increased Fas expression by 8.4 +/- 1.2 % in HIV ( - ) donors
Graninger et al., Cell Death Differ 2000
(Lupus Erythematosus, Systemic) :
IL-2, IL-4, IL-7 and
IL-15 led to a significant increase in
Bcl-2 and a reduction in cell death rates, which was even more pronounced in SLE
Aringer et al., Rheumatology (Oxford) 2001
(Arthritis, Rheumatoid...) :
Both lymphocyte CD25 and
Bcl-2 expression significantly correlated with serum IL-15 and were
increased by recombinant
IL-15
Rappl et al., Cell Death Differ 2001
(Dermatitis) :
Moreover,
IL-15 increases
Bcl-2 and decreases CD95/Fas expression of CD7 ( - ), but not of CD7 ( + ) T cells
Rutella et al., Cytokines Cell Mol Ther 2000
:
Furthermore, T-cell preincubation with a gammac blocking antibody was capable of abrogating both apoptosis inhibition and
Bcl-2 induction by
IL-15
Rutella et al., Exp Hematol 2001
(Hematologic Neoplasms) :
Addition of a gammac blocking antibody to cytokine conditioned cultures abrogated both apoptosis inhibition and
Bcl-2 induction by
IL-15 , suggesting involvement of the IL-2Rgammac signal transduction pathway
Wu et al., J Immunol 2002
(Lymphopenia) :
Moreover, exogenous
IL-15 both
up-regulated the level of
Bcl-2 in and reduced the death rate of wild-type and mutant CD8 ( + ) T cells activated in vitro ... These results indicate that
IL-15 and IL-15Ralpha
regulate the expression of
Bcl-2 in CD8 ( + ) T cells at all developmental stages
Kurowska et al., J Immunol 2002
(Arthritis, Rheumatoid) :
Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex : endogenous
IL-15 in autocrine fashion
enhances cell proliferation and expression of Bcl-x ( L ) and
Bcl-2 ... Next, we investigated the
effects of exogenous or endogenous
IL-15 on
Bcl-2 and Bcl-x ( L ) expression, FLS proliferation, and apoptosis ... We found that blocking
IL-15 biological activities using this protein substantially
reduced endogenous expression of
Bcl-2 and Bcl-x ( L ), and RA FLS proliferation that was reflected by increased apoptosis
Tourkova et al., J Leukoc Biol 2002
(Prostatic Neoplasms) :
Furthermore, transduction of DC with the IL-15 gene significantly increased their resistance to prostate cancer induced apoptosis : Overexpression of
IL-15 on DC
blocked tumor induced inhibition of
Bcl-2 expression and prolonged DC survival after coincubation with tumor cells
Ilangumaran et al., J Immunol 2003
(Lymphoproliferative Disorders) :
However,
IL-15 and IL-2
induce comparable levels of
Bcl-2 and Bcl-x ( L ) in SOCS1-deficient and SOCS1-sufficient CD8+ T cells, suggesting that cytokine receptor signals required for inducing proliferation and cell survival signals are not identical
Crawley et al., Int Immunol 2009
:
We show here that ( i ) memory cells ( CD127+CD45RA- ) divide frequently in response to either IL-2, -4 or -15 ; ( ii ) IL-2 and -15 enhance cell division in effector-memory-like cells ( CD127-CD45RA+ ) while IL-4 enhances the cell division of effector cells ( CD127-CD45RA- ) ; ( iii ) CD8+CD127+ T cells are more sensitive to the anti-apoptotic effects of IL-2 or IL-15 than CD8+CD127- T cells and ( iv ) CD8+CD127+ T cell produce more
Bcl-2 in
response to IL-2 or
IL-15 compared with CD8+CD127- T cells
Sandau et al., J Immunol 2010
(Listeriosis) :
In addition to these qualitative changes,
IL-15 deficiency
resulted in reduced cell cycle and impaired
Bcl-2 expression by 2 degrees memory CD8 T cells, suggesting a role for IL-15 in supporting both basal proliferation and survival of the pool