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NOS2 — S100B

Text-mined interactions from Literome

Petrova et al., Brain Res 2000 : The astrocyte derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide ( NO ) in astrocytes [ Hu et al., 1996, J. Biol. Chem. 271 : 2543 ], but its effect on microglia is not known
Koppal et al., Neurochem Int 2001 (Inflammation) : S100B83stop also stimulated both iNOS and IL-1 beta, although S100B83stop was significantly less effective than wild-type S100B in inducing iNOS
Lam et al., Neurobiol Aging 2001 (Alzheimer Disease) : We report here that S100B stimulates iNOS in rat primary cortical astrocytes through a signal transduction pathway that involves activation of the transcription factor NFkappaB ... Furthermore, S100B induced iNOS promoter activation was inhibited upon mutation of the NFkappaB response element in the promoter, and transfection of cells with an NFkappaB inhibitor blocked S100B induced iNOS promoter activation and nitric oxide production
Cirillo et al., Neurogastroenterol Motil 2009 (Colitis, Ulcerative) : Exogenous S100B induced a significant increase in both iNOS expression and NO production in controls and UC patients ; this increase was inhibited by specific anti-RAGE blocking antibody ... LPS + IFN-gamma induced S100B up-regulation was not affected by budesonide, while iNOS expression and NO production were significantly inhibited by both specific anti-RAGE and anti-S100B blocking antibodies
Ralay Ranaivo et al., Brain Res 2010 (MAP Kinase Signaling System) : Albumin activated ERK1/2, p38 MAPK and JNK signaling pathways in astrocytes, and induced the production of interleukin (IL)-1beta, inducible nitric oxide (NO) synthase , the NO metabolite nitrite, and the chemokine CX3CL1 while reducing the level of S100B