Gene interactions and pathways from curated databases and text-mining

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AGTR2 — EDN1

Pathways - manually collected, often from reviews:

  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: G-alpha-s/GTP complex (GNAS) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
  • BioCarta chrebp regulation by carbohydrates and camp: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) (modification, collaborate)
  • BioCarta chrebp regulation by carbohydrates and camp: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GTP/G-alpha-S complex (GNAS) (modification, collaborate)
  • BioCarta chrebp regulation by carbohydrates and camp: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  • BioCarta chrebp regulation by carbohydrates and camp: GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  • BioCarta ß-arrestins in gpcr desensitization: ligand/GPCR complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → G-protein Receptor (HTR2C/ADRA1B/AGTR2/CHRM1/CCR5/PTGER1/P2RY2/CCR3/EDNRB/EDNRA/CXCR4/FPR1/ADRB2) (degradation, collaborate)
  • BioCarta activation of camp-dependent protein kinase pka: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
  • BioCarta activation of camp-dependent protein kinase pka: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  • BioCarta activation of camp-dependent protein kinase pka: G-alpha-s/GTP complex (GNAS) → G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
  • BioCarta activation of camp-dependent protein kinase pka: G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  • BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) (modification, collaborate)
  • BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → G-alpha-s/GTP complex (GNAS) (modification, collaborate)
  • BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  • BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, activates)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, activates)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: g-gamma/g-beta complex (GNGT1-GNB1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Arrestin (ARRB1) (modification, collaborate)

Text-mined interactions from Literome

Luo et al., Sheng Li Xue Bao 1999 : The effects of endothelin-1 (ET-1) on pulmonary surfactant ( PS ) synthesis of cultured alveolar type II cells (AT II) were observed
Ohanian et al., Arterioscler Thromb Vasc Biol 2001 : In contrast, endothelin induced a biphasic response, with activation at 2 and 10 minutes
Lakó-Futó et al., Circulation 2003 (Cardiomyopathy, Hypertrophic...) : In contrast, AT2-R blockade resulted in a marked increase in the gene expression of c-fos, endothelin-1 , and insulin-like growth factor-1 in Ang II-induced hypertension ... In contrast, AT2-R blockade resulted in a marked increase in the gene expression of c-fos, endothelin-1 , and insulin-like growth factor-1 in Ang II-induced hypertension
Lerch et al., J Cardiovasc Pharmacol 1998 (Genetic Predisposition to Disease...) : Effects of angiotensin II-receptor blockade with losartan on insulin sensitivity, lipid profile, and endothelin in normotensive offspring of hypertensive parents