◀ Back to APOB

APOB — TGFB1

Text-mined interactions from Literome

Di Paolo et al., Clin Exp Immunol 1999 : Thus, the combined effect of CsA and low-density lipoprotein (LDL) on the gene and protein expression of MCP-1 and TGF-beta 1 in cultured human mesangial cells ( HMC ) was explored
Lee et al., Am J Physiol 1999 : To explore the possible molecular mechanisms by which LDL promotes collagen gene expression, we examined the effects of LDL on protein kinase C ( PKC ) activity and transforming growth factor-beta ( TGF-beta ) expression in relation to collagen gene regulation in HMC
Chen et al., Circ Res 2001 : Treatment of HCAECs with a monoclonal antibody to LOX-1 attenuated ox-LDL mediated upregulation of TGF-beta(1) receptors and decrease in TGF-beta(1) synthesis ( P < 0.05 versus ox-LDL alone )
Zhou et al., Zhonghua Yi Xue Za Zhi 2002 : Furthermore, the functional and structural results showed that Ox-LDL regulates rat TGF-beta(1) gene expression through AP-1 binding site and c-Jun/AP-1 complex, it gives rise to the involvement of protein kinase C, but not p38MAPK, in Ox-LDL induced TGF-beta(1) gene expression
Lan et al., Chin Med J (Engl) 2004 : NF-kappa B involved in transcription enhancement of TGF-beta 1 induced by Ox-LDL in rat mesangial cells ... Ox-LDL induced the transcription of TGF-beta1 in a time and dose dependent manner ... NF-kappa B may be involved in the enhancement of TGF-beta 1 induced by Ox-LDL in rat mesangial cells
Wu et al., Cell Biochem Funct 2004 : Because Ox-LDL increases TGF-beta(1) mRNA levels in rat mesangial cells, our investigation was designed to characterize these effects on the rat TGF-beta(1) promoter activity ... The Ox-LDL induced TGF-beta(1) promoter activation was also prevented by inhibitors of protein kinase C, but not by p38 mitogen activated protein kinase ... The functional and structural results show that Ox-LDL regulates rat TGF-beta(1) gene expression through AP-1 binding sites and gives rise to the involvement of protein kinase C in Ox-LDL induced TGF-beta(1) gene expression
Sohn et al., Kidney Int 2005 : Inhibition of p38 ( mapk ) or p42/44(mapk) activities did not affect LDL induced TGF-beta1 , CTGF, and collagen I expression, whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta, CTGF, and collagen I expression
Song et al., Kidney Int 2005 : Quiescent HMC were incubated with 50 microg/mL of Cu ( ++ ) -catalyzed Ox-LDL for 15 minutes to 4 hours, and the effects of Ox-LDL on TGF-beta1 and PAI-1 mRNA expression, PAI-1 promoter activity, and DNA binding activity of Smad proteins were examined ... Ox-LDL induced TGF-beta1 and PAI-1 mRNA expression
Sohn et al., Am J Physiol Heart Circ Physiol 2006 : Inhibition of p38 ( mapk ) activities did not affect LDL induced TGF-beta1 , CTGF, and collagen IV expression
Hakala et al., Arterioscler Thromb Vasc Biol 2006 (Inflammation) : Using cytokine cDNA arrays, we found that H-LDL induced expression of IL-8, but not of the anti-inflammatory cytokines IL-10 and transforming growth factor ( TGF ) -beta , in human monocyte derived macrophages
Song et al., Translational research : the journal of laboratory and clinical medicine 2008 (MAP Kinase Signaling System) : Quiescent mesangial cells were incubated for 18 h with and without the presence of lovastatin before 50 microg/mL of Ox-LDL treatment for 1 h. Lovastatin inhibited markedly the stimulatory effects of Ox-LDL on ERK1/2 activation, nuclear Smad3 expression, TGF-beta1 and PAI-1 mRNA and protein expression, and PAI-1 luciferase activity ... Similar to lovastatin, FTI-277, which is an inhibitor of Ras farnesylation, decreased the Ox-LDL induced activation of ERK/Smad3 and induction of TGF-beta1/PAI-1
Kojima et al., J Cell Biol 1991 : Lipoprotein (a) inhibits the generation of transforming growth factor beta : an endogenous inhibitor of smooth muscle cell migration
Murthy et al., Am J Physiol 1996 : In pulse-chase experiments, IL-6 decreased the rate of synthesis and secretion of apo B-100 and apo B-48 without altering the rate of apo B degradation, whereas TGF-beta 1 increased the rate of synthesis and secretion of apo B-100 and apo B-48
Ding et al., Kidney Int 1997 : To explore the possible molecular mechanisms of lipid induced glomerular injury, the present investigation was conducted to examine the effects of oxidized LDL ( ox-LDL ) on the expression of transforming growth factor ( TGF ) -beta and fibronectin by cultured human glomerular epithelial cells ( GEC )
Nishida et al., Am J Kidney Dis 1997 : Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of interleukin-6, platelet derived growth factor, and transforming growth factor-beta by mesangial cells, whereas tumor necrosis factor-alpha secretion was stimulated by oxidized LDL