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APAF1 — E2F1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Moroni et al., Nat Cell Biol 2001
:
Apaf-1 is a transcriptional
target for
E2F and p53 ... Here we show that
E2F1 directly
regulates the expression of
Apaf-1 , the gene for apoptosis protease activating factor 1
Wright et al., J Cell Biol 2007
:
Surprisingly, we find that
E2F1 is
sufficient to induce
Apaf-1 expression in developing but not mature neurons ... Rather,
Apaf-1 up-regulation in mature neurons
requires both chromatin derepression and
E2F1 transcriptional activity ... This differential capacity of
E2F1 to
induce Apaf-1 transcription is because of the association of the Apaf-1 promoter with active chromatin in developing neurons and repressed chromatin in mature neurons
Johnson et al., Proc Natl Acad Sci U S A 2007
(Astrocytoma...) :
ChIP assays reveal that E2F1 binds the Apaf-1 promoter specifically in tumor tissue, suggesting that
E2F1 contributes to the expression of
Apaf-1 in brain tumors