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CUL4A — DDB2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Kulaksiz et al., Mol Cell Biol 2005
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Olma et al., J Cell Sci 2009
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Guerrero-Santoro et al., Cancer Res 2008*
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Angers et al., Nature 2006
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Kapetanaki et al., Proc Natl Acad Sci U S A 2006*
• IRef Biogrid Interaction: DDB2 — CUL4A (direct interaction, pull down) Jin et al., Mol Cell 2006
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Higa et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Matsuda et al., DNA repair 2005*
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Nag et al., Mol Cell Biol 2001*
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Takedachi et al., Mol Cell Biol 2010*
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Fischer et al., Cell 2011*
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Tan et al., J Virol 2007*
• IRef Biogrid Interaction: DDB2 — CUL4A (colocalization, biochemical) He et al., Genes Dev 2006
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) He et al., Genes Dev 2006
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Groisman et al., Cell 2003
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Hrecka et al., Proc Natl Acad Sci U S A 2007
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Shiyanov et al., J Biol Chem 1999*
• IRef Biogrid Interaction: DDB2 — CUL4A (association, biochemical) Shiyanov et al., J Biol Chem 1999*
• IRef Biogrid Interaction: DDB2 — CUL4A (physical association, affinity chromatography technology) Bennett et al., Cell 2010
• MIPS CORUM Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1): Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) complex (CUL4A-CUL4B-DDB1-DDB2-RBX1) Wang et al., Mol Cell 2006*
• MIPS CORUM DDB2 complex: DDB2 complex complex (COPS2-COPS3-COPS4-COPS5-COPS6-COPS8-CUL4A-DDB1-DDB2-GPS1-RBX1-COPS7A-COPS7B) Groisman et al., Cell 2003
• IRef Corum Interaction: Complex of 11 proteins (association, ion exchange chromatography) Wang et al., Mol Cell 2006*
• IRef Corum Interaction: Complex of 27 proteins (association, cosedimentation through density gradient) Groisman et al., Cell 2003
• IRef Hprd Interaction: DDB2 — CUL4A (in vivo) Guerrero-Santoro et al., Cancer Res 2008*
• IRef Intact Interaction: Complex of 22 proteins (association, tandem affinity purification) Fang et al., J Proteome Res 2008
• IRef Intact Interaction: Complex of 32 proteins (physical association, tandem affinity purification) Hutchins et al., Science 2010
• IRef Intact Interaction: Complex of 36 proteins (physical association, anti tag coimmunoprecipitation) Sowa et al., Cell 2009
• IRef Intact Interaction: Complex of 55 proteins (physical association, anti tag coimmunoprecipitation) Sowa et al., Cell 2009
• IRef Intact Interaction: DDB2 — CUL4A (physical association, anti bait coimmunoprecipitation) Higa et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 15 proteins (association, anti bait coimmunoprecipitation) Higa et al., Nat Cell Biol 2006
• IRef Ophid Interaction: DDB2 — CUL4A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: CUL4A — DDB2 (interaction, mapped from grid)
• STRING interaction: DDB2 — CUL4A (interaction, mapped from grid mint intact)

Text-mined interactions from Literome

Nag et al., Mol Cell Biol 2001 : Because cullins are involved in the ubiquitin-proteasome pathway, we investigated the role of Cul-4A in regulating DDB2
El-Mahdy et al., J Biol Chem 2006 : Here, we have provided evidence that Cullin 4A (CUL-4A) , a key component of CUL-4A based ubiquitin ligase, mediates DDB2 degradation at the damage sites and regulates the recruitment of XPC and the repair of cyclobutane pyrimidine dimers ... These results suggest that CUL-4A mediates the proteolytic degradation of DDB2 and that this degradation event, initiated at the lesion sites, regulates damage recognition by XPC during the early steps of NER
Chen et al., Mol Cell 2006 : Biochemical studies revealed that c-Abl promotes CUL-4A mediated DDB ubiquitination and degradation in a manner that does not require its tyrosine kinase activity both under normal growth conditions and following UV irradiation