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IL6 — NOTCH2

Text-mined interactions from Literome

Bhoopathi et al., Cancer Res 2011 (Brain Neoplasms...) : Taken together, our results suggest that SPARC induces expression of neuronal markers in medulloblastoma cells through its inhibitory effect on IL-6 regulated suppression of Notch pathway mediated STAT3 signaling, thus giving further support to the potential use of SPARC as a therapeutic candidate for medulloblastoma treatment
Zhang et al., J Biol Chem 2012 (Inflammation...) : Importantly, overexpression of constituted active form of Notch1 ( NICD1 ) and Notch2 ( NICD2 ) suppressed production of TLR4 triggered proinflammatory cytokines such as TNF-a and IL-6 but promoted production of antiinflammatory cytokine IL-10, which is dependent on the PEST domain of NICD