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HTT — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
HTT
—
TP53
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Bind_translation Interaction:
HTT
—
TP53
(experimental interaction detection)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Bind_translation Interaction:
HTT
—
TP53
(affinity chromatography technology)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Bind_translation Interaction:
HTT
—
TP53
(coimmunoprecipitation)
Bae et al., Neuron 2005*
-
IRef Bind_translation Interaction:
HTT
—
TP53
(affinity chromatography technology)
Bae et al., Neuron 2005*
-
IRef Biogrid Interaction:
HTT
—
TP53
(direct interaction, pull down)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Biogrid Interaction:
HTT
—
TP53
(physical association, affinity chromatography technology)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Hprd Interaction:
TP53
—
HTT
(in vivo)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Hprd Interaction:
TP53
—
HTT
(in vitro)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Intact Interaction:
HTT
—
TP53
(physical association, biochemical)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Intact Interaction:
HTT
—
TP53
(physical association, pull down)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Ophid Interaction:
HTT
—
TP53
(aggregation, confirmational text mining)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Ophid Interaction:
HTT
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Bae et al., Neuron 2005
(Huntington Disease...) :
Mutant
huntingtin ( mHtt ) with expanded polyglutamine ( polyQ ) binds to p53 and
upregulates levels of nuclear
p53 as well as p53 transcriptional activity in neuronal cultures
Feng et al., Oncogene 2006
(Huntington Disease) :
Similarly, murine
huntingtin also contains multiple putative p53-responsive elements and its expression is
induced by
p53 activation in cultured cells
Ryan et al., Neurobiol Dis 2006
(Disease Models, Animal...) :
It has recently been shown that activation of
p53 upregulates the level of
huntingtin , both in vitro and in vivo, whereas p53 deficiency in HD-transgenic flies and mice has been found to be beneficial ...
p53 deficiency
resulted in a reduction of mutant
huntingtin expression in brain and testis, an increase in proenkephalin mRNA expression and a significant increase in nuclear aggregate formation in the striatum
Anne et al., J Neurosci 2007
(Huntington Disease) :
Absence of phosphorylation of
huntingtin at serines 1181 and 1201 confers toxic properties to wild-type huntingtin in a
p53 dependent manner in striatal neurons and accelerates neuronal death induced by DNA damage