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PRKAR1B — SMAD3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sowa et al., J Biol Chem 2003
:
Protein kinase A (PKA) activator as well as protein kinase C ( PKC ) activators
increased Smad3 protein level, and both PKA and PKC inhibitors antagonized PTH induced Smad3, indicating that PTH promotes the production of Smad3 through both PKA and PKC pathways
Schiller et al., Oncogene 2003
:
Inhibition of
protein kinase A (PKA) , the main downstream effector of cAMP, with H-89,
suppressed cAMP dependent repression of
SMAD-driven gene expression ... cAMP elevating agents did not inhibit nuclear translocation and DNA binding of SMAD3/4 complexes, but abolished the interactions of
SMAD3 with the transcription coactivators CREB binding protein (CBP) and p300 in a
PKA dependent manner