◀ Back to MAPK1
MAPK1 — RUNX2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Pei et al., Acta Pharmacol Sin 2003
(MAP Kinase Signaling System) :
And
mitogen activated protein kinase ( MAPK ) inhibitor, PD 98059 ( 10 micromol/L ), completely
blocked IGF-1, GM-CSF, and EGF induced expression of
Cbfa1 promoter activity ( P < 0.01 )
Costessi et al., Bone 2005
:
In fact, by using the specific inhibitors SB203580 ( specific for p38 MAPK ) and PD98059 ( specific for ERK-1/2 MAPK ), we found that
ERK-1/2 , but not p38,
play a major role in
Runx2 activation
Celil et al., J Biol Chem 2005
:
PKC/D and
MAPK signaling also
mediate Runx2 activity
Kanno et al., J Cell Biochem 2007
(MAP Kinase Signaling System) :
Mechanical stress mediated
Runx2 activation is
dependent on Ras/ERK1/2
MAPK signaling in osteoblasts ... We examined the
involvement of diverse mitogen activated protein kinase (
MAPK ) pathways in the activation of
Runx2 during mechanical stress
Franceschi et al., Ann N Y Acad Sci 2007
:
MAPK activation of
RUNX2 was also found to occur in vivo
Lee et al., J Bone Miner Res 2008
:
Taken together, these findings indicate that BBR promotes osteoblast differentiation through
activation of
Runx2 by p38
MAPK
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
In this study we determined the effect of a standardized pomegranate extract ( PE ) on the IL-1ß induced activation of MKK3/6,
p38-MAPK isoforms and the
activation of transcription factor
RUNX-2 in primary human OA chondrocytes
Ge et al., J Bone Miner Res 2012
(MAP Kinase Signaling System) :
Significantly, in the presence of AA, BMP2/7 synergistically stimulated
RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally
dependent on
ERK/MAPK activity
Li et al., J Bone Miner Res 2012
:
These findings establish
ERK/MAPK mediated phosphorylation of
RUNX2 as a critical step in the response of preosteoblasts to dynamic loading and define a novel mechanism to explain how mechanical signals induce gene expression in bone
Yue et al., Biochim Biophys Acta 2013
:
Similar results were obtained in experiments performed in the native tissue in which inhibition of ERK and p38
MAPK increased BK channel activity in the cortical
collecting duct (CCD) treated with dynasore