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RHO — SRC
Text-mined interactions from Literome
Fincham et al., J Cell Sci 1999
(Cell Transformation, Neoplastic) :
Regulation of p190
Rho-GAP by
v-Src is linked to cytoskeletal disruption during transformation
Hunt et al., J Am Soc Nephrol 2005
(Calcium Signaling) :
Screening with modulators of specific signaling pathways identified reversible increases in flux with
Src tyrosine and
Rho kinase
inhibition
Vulin et al., Endocrinology 2005
:
Src increased prolactin gene transcription was inhibited by expression of a blocking Rho-mutant ( RhoN19 ), suggesting that
Src acted through or
required active
Rho
Samarakoon et al., J Mol Cell Cardiol 2008
:
Thus, two distinct pathways involving the
EGFR/pp60(c-src)/MEK-ERK pathway and
Rho/ROCK dependent SMAD2
activation are required for TGF-beta1 induced PAI-1 expression in VSMC
Granot-Attas et al., Mol Biol Cell 2009
:
Increasing
Src activity or
inhibiting Rho or its downstream effector Rho kinase in EKO osteoclasts rescues their podosomal stability phenotype, indicating that cyt-PTPe affects podosome stability by functioning upstream of these molecules
Tripathi et al., Mol Cell Biol 2009
:
Next, we examined the effect of Cdk5 activity on
Src , a known
regulator of
Rho
Arpaia et al., Oncogene 2012
(Neoplasm Metastasis...) :
Rho-GTPases are important regulators of p130 ( Cas ), which is crucial for both normal cell migration and
Src kinase
mediated metastasis of cancer cells
Basavarajappa et al., Mol Cell Biol 2011
:
We also found that
rhodopsin regulated
Src kinase activation in retina leads to the phosphorylation of Grb14