Gene interactions and pathways from curated databases and text-mining

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SHC1 — SRC

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Blaukat et al., J Biol Chem 1999 : Pyk2 induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb2 and Crk, respectively, and for the activation of ERK and JNK cascades
Park et al., J Immunol 1999 : The Src family tyrosine kinase inhibitor, PP1, was shown to completely inhibit Shc tyrosine phosphorylation, the Shc-Grb2 interaction, and the FcgammaR induced respiratory burst
Goi et al., EMBO J 2000 : Also, c-Src activated by EGF treatment or expression of constitutively activated Ral-GTPase led to tyrosine phosphorylation of Stat3 and cortactin, but not Shc or subsequent Erk activation ... In contrast, c-Src activated by isoproterenol led to tyrosine phosphorylation of Shc and subsequent Erk activation, but not tyrosine phosphorylation of cortactin or Stat3
Barnes et al., Oncogene 2003 : v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor related protein 1
Leu et al., Biochem Pharmacol 2003 : Consistent with the abrogation of Src activity was the reduction of Src-Tyr-416 phosphorylation, Src mediated Shc-Tyr-317 phosphorylation, decreased ERK activation, and cell proliferation in v-Src transformed cells
Sato et al., J Biochem 2005 : In a previous study, we presented evidence that the adaptor protein Shc interacts with and activates the tyrosine kinase c-Src without affecting the phosphorylation state of Tyr-527 in c-Src ... Here we show that Shc mediated c-Src activation occurs in mitotic NIH 3T3 cells ... These results support the idea that dephosphorylation independent activation of c-Src by Shc is mediated by a molecular interaction involving the c-Src IDA region
Lieskovska et al., J Biol Chem 2006 (MAP Kinase Signaling System) : These studies were undertaken to determine whether Src kinase activity is required to phosphorylate Shc in response to IGF-I in SMC and because SHP-2 binds to Src whether their interaction was also required for IGF-I stimulated mitogenesis
Kleiner et al., FEBS J 2007 (MAP Kinase Signaling System) : We explored the underlying molecular mechanisms and found that blockage of E-cadherin by Decma elicits a signaling pathway downstream of E-cadherin that leads to Src dependent Shc and extracellular regulated kinase (Erk) activation and results in uPAgene activation
Li et al., Am J Physiol Cell Physiol 2007 (MAP Kinase Signaling System) : ANG II induced a Src dependent association between Shc and growth factor receptor bound protein 2 ( Grb2 ) and between Grb2 and son of sevenless ( Sos ), both of which were maximal at 15 min
Harrington et al., Obesity (Silver Spring) 2007 : Src inhibitors PP1 and PP2 blocked ERK and p38 activation by low but not high EGF, and only high EGF increased Shc phosphorylation
Sirvent et al., Oncogene 2007 (Breast Neoplasms...) : Abl does not mediate tyrosine phosphorylation of Stat3 and Shc , two important regulators of Src oncogenic activity
Sachdev et al., BMC cancer 2009 (Colonic Neoplasms...) : The Src induced phosphorylation of Eps8, PLC-gamma 1 and Shc ( poY239/poY240 ) were not affected by either FAK or adherence status
Luttrell et al., J Biol Chem 1996 : Overexpression of wild-type or constitutively active mutant c-Src , but not kinase inactive mutant c-Src, lead to increased tyrosine kinase activity in Shc immunoprecipitates, increased Shc tyrosine phosphorylation, and Shc.Grb2 complex formation
Sato et al., Biochem Biophys Res Commun 1998 : c-Src and phosphatidylinositol 3-kinase are involved in NGF dependent tyrosine phosphorylation of Shc in PC12 cells