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SHC1 — SRC
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
SHC1
→
SRC
(directlyIncreases, SHC1 Activity)
Evidence: 11075717;9121430;9710204;10891441;11687594;15592455;9927207
-
OpenBEL Selventa BEL large corpus:
SHC1
→
SRC
(directlyIncreases, SHC1 Activity)
Evidence: 11075717;9121430;9710204;15592455;9927207
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1)
→
SHC (SHC1)
(modification, collaborate)
-
BioCarta erk1/erk2 mapk signaling pathway:
SRC
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta calcium signaling by hbx of hepatitis b virus:
PYK2/SRC complex (PTK2B-SRC)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC)
→
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Song et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC)
→
p52 SHC (SHC1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Song et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
→
p52 SHC (SHC1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Song et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
IGF1 (IGF1)
→
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
(modification, collaborate)
Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
→
IGF-1R heterotetramer complex (IGF1R)
(modification, activates)
Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
→
IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1)
(modification, activates)
Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
→
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
Evidence: physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
Evidence: physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
Evidence: physical interaction
-
NCI Pathway Database EPHB forward signaling:
GRB2 (GRB2)
→
Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2)
(modification, collaborate)
Vindis et al., J Cell Biol 2003
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC)
→
p52 SHC (SHC1)
(modification, collaborate)
Vindis et al., J Cell Biol 2003
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC)
→
Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2)
(modification, collaborate)
Vindis et al., J Cell Biol 2003
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
p52 SHC (SHC1)
→
Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2)
(modification, collaborate)
Vindis et al., J Cell Biol 2003
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
SHC1
→
SRC
(indirect_complex)
Cowan et al., J Biol Chem 2000*, Law et al., J Biol Chem 1996*, Bonfini et al., Trends Biochem Sci 1996*
-
Reactome Reaction:
SHC1
→
SRC
(reaction)
Law et al., J Biol Chem 1996*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
SRC
—
SHC1
Marengere et al., Nature 1994*, van der Geer et al., Curr Biol 1996*
-
IRef Bind_translation Interaction:
SRC
—
SHC1
(experimental interaction detection)
Marengere et al., Nature 1994*, van der Geer et al., Curr Biol 1996*
-
IRef Bind_translation Interaction:
SRC
—
SHC1
(surface plasmon resonance)
Marengere et al., Nature 1994*
-
IRef Bind_translation Interaction:
SRC
—
SHC1
(affinity chromatography technology)
Marengere et al., Nature 1994*
-
IRef Hprd Interaction:
SRC
—
SHC1
(in vivo)
Marchetto et al., Leukemia 1999*, Yamaguchi et al., Leukemia 1997*, Sato et al., Biochem Biophys Res Commun 1997*, Walk et al., Eur J Immunol 1998
-
IRef Hprd Interaction:
Complex of 73 proteins
(in vivo)
Schulze et al., Molecular systems biology 2005
-
IRef Ophid Interaction:
SRC
—
SHC1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
STRING interaction:
SRC
—
SHC1
(interaction, mapped from kegg_pathways)
-
STRING interaction:
SRC
—
SHC1
(interaction, mapped from kegg_pathways)
-
STRING interaction:
SHC1
—
SRC
(interaction, mapped from kegg_pathways)
-
STRING interaction:
SHC1
—
SRC
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Blaukat et al., J Biol Chem 1999
:
Pyk2 induced activation of
Src is
necessary for phosphorylation of
Shc and p130Cas and their association with Grb2 and Crk, respectively, and for the activation of ERK and JNK cascades
Park et al., J Immunol 1999
:
The
Src family tyrosine kinase inhibitor, PP1, was shown to completely
inhibit Shc tyrosine phosphorylation, the
Shc-Grb2 interaction, and the FcgammaR induced respiratory burst
Goi et al., EMBO J 2000
:
Also,
c-Src activated by EGF treatment or expression of constitutively activated Ral-GTPase
led to tyrosine phosphorylation of Stat3 and cortactin, but not
Shc or subsequent Erk activation ... In contrast,
c-Src activated by isoproterenol led to tyrosine phosphorylation of
Shc and subsequent Erk activation, but not tyrosine phosphorylation of cortactin or Stat3
Barnes et al., Oncogene 2003
:
v-Src induces
Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor related protein 1
Leu et al., Biochem Pharmacol 2003
:
Consistent with the abrogation of Src activity was the reduction of Src-Tyr-416 phosphorylation,
Src mediated
Shc-Tyr-317 phosphorylation, decreased ERK activation, and cell proliferation in v-Src transformed cells
Sato et al., J Biochem 2005
:
In a previous study, we presented evidence that the adaptor protein
Shc interacts with and
activates the tyrosine kinase
c-Src without affecting the phosphorylation state of Tyr-527 in c-Src ... Here we show that
Shc mediated
c-Src activation occurs in mitotic NIH 3T3 cells ... These results support the idea that dephosphorylation independent
activation of
c-Src by
Shc is mediated by a molecular interaction involving the c-Src IDA region
Lieskovska et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
These studies were undertaken to determine whether
Src kinase activity is
required to phosphorylate
Shc in response to IGF-I in SMC and because SHP-2 binds to Src whether their interaction was also required for IGF-I stimulated mitogenesis
Kleiner et al., FEBS J 2007
(MAP Kinase Signaling System) :
We explored the underlying molecular mechanisms and found that blockage of E-cadherin by Decma elicits a signaling pathway downstream of E-cadherin that leads to
Src dependent
Shc and extracellular regulated kinase (Erk) activation and results in uPAgene activation
Li et al., Am J Physiol Cell Physiol 2007
(MAP Kinase Signaling System) :
ANG II induced a
Src dependent association between
Shc and growth factor receptor bound protein 2 ( Grb2 ) and between Grb2 and son of sevenless ( Sos ), both of which were maximal at 15 min
Harrington et al., Obesity (Silver Spring) 2007
:
Src inhibitors PP1 and PP2 blocked ERK and p38 activation by low but not high EGF, and only high EGF
increased Shc phosphorylation
Sirvent et al., Oncogene 2007
(Breast Neoplasms...) :
Abl does not mediate tyrosine phosphorylation of Stat3 and
Shc , two important
regulators of
Src oncogenic activity
Sachdev et al., BMC cancer 2009
(Colonic Neoplasms...) :
The
Src induced phosphorylation of Eps8, PLC-gamma 1 and
Shc ( poY239/poY240 ) were not affected by either FAK or adherence status
Luttrell et al., J Biol Chem 1996
:
Overexpression of wild-type or constitutively active mutant
c-Src , but not kinase inactive mutant c-Src,
lead to increased tyrosine kinase activity in Shc immunoprecipitates, increased
Shc tyrosine phosphorylation, and Shc.Grb2 complex formation
Sato et al., Biochem Biophys Res Commun 1998
:
c-Src and phosphatidylinositol 3-kinase are
involved in NGF dependent tyrosine phosphorylation of
Shc in PC12 cells