Gene interactions and pathways from curated databases and text-mining

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MMP9 — NA

Text-mined interactions from Literome

Kawakami et al., Anticancer Res 2001 (Neoplasm Invasiveness...) : TPA increased the MMP-9 production by T24 cells without altering expression of TIMP-1 gene, while NAC suppressed TPA enhanced production of MMP-9 ... In vitro experiments demonstrated that MMP-9 was directly inhibited by NAC but was not influenced by TPA
Ollivier et al., Am J Vet Res 2003 (Corneal Ulcer...) : We documented that EDTA, doxycycline, NAC , ilomostat, alpha1PI, and ES inhibited MMP activity in vitro
Mizoguchi et al., J Neurochem 2007 : On the other hand, MMP-2/-9 inhibitors blocked the METH induced behavioral sensitization and conditioned place preference, a measure of the rewarding effect, and reduced the METH increased dopamine release in the NAc
Mizoguchi et al., J Pharmacol Sci 2008 (Amphetamine-Related Disorders...) : MMP-2/-9 inhibitors blocked the METH induced behavioral sensitization and conditioned place preference (CPP), a measure of the rewarding effect of a drug, and reduced the METH increased dopamine release in the NAc
Voronkina et al., Tsitologiia 2008 (Cell Transformation, Viral) : NAC action for 2-6 hours completely inhibited MMP-2 and MMP-9 activity in both cell lines
Radomska-Leśniewska et al., Pharmacol Rep 2010 (Lung Diseases, Interstitial...) : Therefore, the aim of the present work was to evaluate the effect of NAC on interleukin-8 (IL-8) and matrix metalloproteinase-9 (MMP-9) production as well as intercellular cell adhesion molecule-1 ( ICAM-1 ) expression by BAL cells from interstitial lung diseases
Popova et al., Antioxid Redox Signal 2010 : The same effect was achieved by the nontargeted antioxidant Trolox at higher concentration, but the thiol antioxidant N-acetylcysteine (NAC) inhibited MMP activity and was not able to induce myofibroblast differentiation
Li et al., Chem Biol Interact 2010 : DP increased the levels of reactive oxygen species ( ROS ) in HepG2 cells, and antioxidant N-acetylcysteine (NAC) completely blocked DP-induced ROS accumulation and the disruption of the balance between Bax and Bcl-2 proteins, and effectively blocked the decreased MMP and apoptosis, but had no effect on the activation of caspase-8 and the up-regulations of DR4 and DR5 induced by DP
Lu et al., J Atheroscler Thromb 2011 (Plaque, Atherosclerotic) : Moreover, we found that NAC down-regulated the expression of VCAM-1, MMP2 and MMP9, accompanied by inhibition of NF-?B activation and reduced expression of RAGE ... Moreover, we found that NAC down-regulated the expression of VCAM-1, MMP2 and MMP9 , accompanied by inhibition of NF-?B activation and reduced expression of RAGE
Ramaesh et al., Eye (Lond) 2012 : Twenty mM NAC inhibited the secretion of MMP-9 significantly ... This study shows that NAC reduces MMP-9 production by HCE cells and inhibits cell migration in vitro
Zang et al., Int Immunopharmacol 2013 (Lymphoma, Large B-Cell, Diffuse...) : Phagocytosis, the loss of MMP , autophagy and the activated signaling pathways were all suppressed by ROS scavenger N-acetyl-l-cysteine (NAC) , HO scavenger catalase or OH scavenger glutathione ( GSH )