◀ Back to NFKB1
MMP1 — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mengshol et al., Arthritis Rheum 2000
(MAP Kinase Signaling System) :
In chondrosarcoma cells,
MMP-1 induction depends on p38 and MEK ( an MAPK kinase of the extracellular signal regulated kinase pathway ) and does not
require JNK or
NF-kappaB ... In chondrosarcoma cells,
MMP-1 induction depends on p38 and MEK ( an MAPK kinase of the extracellular signal regulated kinase pathway ) and does not
require JNK or
NF-kappaB
Barchowsky et al., Cytokine 2000
(MAP Kinase Signaling System) :
We have reported previously that
NF-kappaB and AP-1 cooperate to
mediate IL-1 induced
MMP-1 transcription
Xu et al., Biochem J 2001
:
Nuclear factor-kappaB (NF-kappaB) , a previously identified positive regulator of
MMP-1 expression induced by fl-coll [ Xu, Zutter, Santoro and Clark ( 1998 ) J. Cell Biol. 140, 709-719 ] was
mediated by fl-coll activated p38alpha
Okuno et al., Scand J Gastroenterol 2002
:
The inhibition of
NF-kappaB activation markedly blocked both IL-1beta- and TNF-alpha induced IL-8 and MCP-1 mRNA expression, but did not
affect MMP-1 mRNA expression
Sun et al., Frontiers in bioscience : a journal and virtual library 2002
(Arthritis, Rheumatoid) :
The results support a stimulatory
role of
NF-kappa B in transcriptional regulation of
MMP-1 and MMP-13
Ferri et al., J Biol Chem 2003
:
Thus, polymerized collagen induces
NF-kappaB dependent expression of
MMP1 and alpha2beta1 integrin, that are required for smooth muscle extracellular matrix remodeling
Shukla et al., Neoplasia (New York, N.Y.) 2004
(Adenocarcinoma...) :
The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of Bcl2, cyclin D1,
MMP-9 , and VEGF
Dai et al., Ann Rheum Dis 2005
(Arthritis...) :
In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1,
MMP-3 , and MMP-13, which was
blocked by
NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor ... In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of
MMP-1 , MMP-3, and MMP-13, which was
blocked by
NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Migita et al., FEBS Lett 2005
:
Although SIN-1 did not enhance the secretions of
MMP-1 and 13, SIN-1
induced the
NF-kappaB activation, MT1-MMP expression and the secretion of activated MMP-2 in LI90 cells
Tanaka et al., J Pharmacol Exp Ther 2005
:
We found that parthenolide could effectively inhibit the gene expression
mediated by
NF-kappaB and the production of bFGF and
MMP-1 from cells overexpressing p65, a major subunit of NF-kappaB
Lu et al., J Immunol 2005
:
Thus, in the presence of LPS and H ( 2 ) O ( 2 ),
NF-kappaB plays a dominate role in the regulation of
MMP-1 , COX-2, and PGE ( 2 ) expression
Mullan et al., Arthritis Rheum 2006
(Arthritis, Rheumatoid...) :
A-SAA induced expression of VCAM-1, ICAM-1, and
MMP-1 was
down-regulated by
NF-kappaB inhibition
Yoshida et al., Respirology 2006
(Pulmonary Emphysema) :
A specific inhibitor of
NF-kappaB reduced
MMP production by alveolar macrophages from SP-D-/- mice
Fan et al., Rheumatol Int 2006
:
Role of mitogen activated protein kinases and
NFkappaB on IL-1beta induced effects on collagen type II,
MMP-1 and 13 mRNA expression in normal articular human chondrocytes ...
Role of mitogen activated protein kinases and
NFkappaB on IL-1beta induced effects on collagen type II,
MMP-1 and 13 mRNA expression in normal articular human chondrocytes ... Inhibitors of ERK and
NFkappaB could significantly
block the induction of
MMP-1 and -13 ( p < 0.05 ) and the repression of collagen type II ( p < 0.01 )
Faour et al., J Biol Chem 2006
(Arthritis, Rheumatoid...) :
Role in suppression of
c/EBP/NF-kappaB mediated MEKK1 induced
MMP-1 expression
Raymond et al., Osteoarthritis Cartilage 2007
(Arthritis) :
MMP-1 gene expression was mirrored by increases in
NF-kappaB gene expression, and inhibition of NF-kappaB nuclear translocation with dominant negative IkappaBalpha
reduced IL-1beta dependent
MMP-1 gene expression
Bachmeier et al., Cell Physiol Biochem 2007
(Breast Neoplasms...) :
68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of
NFkappa B/AP-1 dependent
MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases
Bogatkevich et al., Arthritis Rheum 2007
(MAP Kinase Signaling System...) :
Inhibition of
MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not
prevent HGF induced ERK-1/2 phosphorylation and
NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Cortez et al., Am J Physiol Heart Circ Physiol 2007
:
Inhibition of AP-1,
NF-kappaB , or C/EBP activation
attenuated IL-17 stimulated
MMP-1 expression
Alvarez-Soria et al., Rheumatology (Oxford) 2008
(Osteoarthritis, Knee) :
The effects of diacerein, celecoxib, diclofenac, meloxicam and indomethacin on prostaglandin ( PG ) E2 production, cyclo-oxygenase-2 (COX-2) protein expression, nitrite levels, presence of
MMP-1 and -13, and
activation of
nuclear factor-kappaB (NF-kappaB) were studied on stimulated OA synoviocytes and chondrocytes
Castier et al., Antioxid Redox Signal 2009
:
Hence, induction of
NF-kappaB by shear stress
contributes to
MMP induction and allows long-term flow induced vascular enlargement
Nakatani et al., Arch Oral Biol 2009
:
Effects of specific inhibitors of p38 mitogen activated protein kinase ( MAPK ) activity, MAPK kinase activity and
NFkB activity on HAoligo induced
MMP-1 expression in HPDL cells were also investigated by real-time PCR and Western blot analyses ... Neither inhibition of
NFkB nor MAPKK activity
affected the
MMP-1 expression
Lee et al., Exp Dermatol 2010
:
In addition,
NF-kappaB or JNK
mediated the
MMP-1 expression induced by TLR2, TLR3 and TLR5, whereas NF-kappaB, JNK or p38 MAPK mediated the MMP-9 expression induced by TLR2, TLR3 and TLR5
Moon et al., Int Immunopharmacol 2010
(Arthritis, Experimental...) :
Additionally, by altering
nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin
inhibited PGE ( 2 ) production, COX-2 expression, and
MMP secretion
Martinez-Orozco et al., Eur J Cell Biol 2010
(Neoplasm Invasiveness) :
We demonstrate here that AA promotes an increase in vimentin and N-cadherin expression,
MMP-9 secretion, a decrease in E-cadherin junctional levels, and the
activation of FAK, Src and
NF-kappaB in MCF10A cells
Green et al., J Immunol 2010
(Tuberculosis, Central Nervous System) :
Chemical inhibition and promoter-reporter analyses showed that
NF-kappaB and AP-1 c-Jun/FosB heterodimers
regulate CoMTb induced
MMP-1/-3 secretion
Tanaka et al., Curr Drug Metab 2010
:
We found that either parthenolide or magnolol could effectively inhibit the gene expression
mediated by
NF-kappaB and the production of bFGF and
MMP-1 from cells overexpressing p65, a major subunit of NF-kappaB
Vincenti et al., Arthritis Rheum 1998
(Arthritis, Rheumatoid) :
These studies demonstrate, for the first time, a
role for
NF-kappaB in the induction of
MMP-1 , and suggest a mechanism of NF-kappaB mediated cartilage degradation in rheumatoid arthritis