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CDH5 — FGF2
Text-mined interactions from Literome
Debiais et al., J Cell Biochem 2001
:
We investigated the
effects of
FGF-2 on cell-cell adhesion and
cadherin expression and the underlying signaling pathways in immortalized human neonatal calvaria ( IHNC ) cells
Ciruna et al., Dev Cell 2001
:
We propose that modulation of cytoplasmic beta-catenin levels, associated with
FGF induced downregulation of
E-cadherin , provides a molecular link between FGF and Wnt signaling pathways at the streak
Wu et al., Exp Cell Res 2008
:
But the mRNA or total protein of cadherins had no significant change, suggesting that the
effect of
bFGF on
cadherin expression may work through a post-translational control
Hatanaka et al., PloS one 2012
:
In vitro studies demonstrated that the loss of
FGF signaling
disrupts the
VE-cadherin-catenin complex at adherens junctions by increasing tyrosine phosphorylation levels of VE-cadherin ... In vitro studies demonstrated that the loss of
FGF signaling
disrupts the
VE-cadherin-catenin complex at adherens junctions by increasing tyrosine phosphorylation levels of VE-cadherin ... Among protein tyrosine phosphatases (PTPs) known to be involved in the maintenance of the VE-cadherin complex, suppression of
FGF signaling
reduces SHP2 expression levels and
SHP2/VE-cadherin interaction due to accelerated SHP2 protein degradation