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IFNG — PML

Text-mined interactions from Literome

Nason-Burchenal et al., Blood 1996 (Leukemia, Promyelocytic, Acute...) : We report here that PML is expressed at low levels or not expressed in normal circulating human monocytes, lymphocytes, and polymorphonucleate cells, but is markedly induced by interferon ; that PML and PML/RAR alpha expression is augmented by interferon in the NB4 APL cell line, which carries the t ( 15 ; 17 ), and in APL blasts from patients ; that interferon inhibits growth and survival of NB4 APL cells in cooperation with RA ; that interferons alone have minimal maturation effect on NB4 cells ; and, finally, that interferon gamma , but not alpha or beta, induces maturation and growth suppression of NB4 cells with de novo retinoid resistance, and partially restores RA response
Aractingi et al., Bone Marrow Transplant 1997 (Chronic Disease...) : PML is induced by interferon (IFN) gamma