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IFNB1 — TCF24
Text-mined interactions from Literome
Takane et al., J Pharmacol Exp Ther 2000
(Melanoma, Experimental) :
The dosing time dependent effect of IFN-beta was supported by the time dependent expression of
transcription factor ( signal transducers and activators of transcription 1 ) and cell proliferation inhibitor ( p21 wild-type p53 activated fragment 1 ) protein
induced by
IFN-beta
Yang et al., J Biol Chem 2001
:
IFN-alpha/beta also
activates another
transcription factor , nuclear factor kappaB (NF-kappaB), which protects cells against apoptotic stimuli
Reis et al., EMBO J 1992
:
Critical
role of a common
transcription factor , IRF-1, in the regulation of
IFN-beta and IFN-inducible genes
Pfeffer et al., J Biol Chem 2004
:
IFN-alpha/beta activates another important
transcription factor , nuclear factor-kappaB (NF-kappaB), but its role in IFN mediated activity is poorly understood
Emori et al., J Gen Virol 2004
:
Further experiments revealed that Z-100 induced
IFN-beta production in these cells,
resulting in induction of the 16-kDa CCAAT/enhancer binding protein (C/EBP) beta
transcription factor that represses HIV-1 long terminal repeat transcription
Molle et al., J Immunol 2007
:
In this study, we first demonstrate that Toll/IL-1R containing adaptor inducing
IFN-beta and its associated IFN regulatory factor (IRF) 3
transcription factor are critically
involved in IL-27p28 expression in mouse DCs stimulated by TLR ligands
Rani et al., J Interferon Cytokine Res 2007
:
TRAIL was not
induced by
IFN-beta in mutant cell lines U2A, U3A, U4A, U5A, and U6A, which lack, respectively, IFN regulatory factor-9 (IRF-9), Stat1, Jak1, IFNAR-2.2, and Stat2, indicating
transcription factor IFN stimulated gene factor 3 ( ISGF3 ) was essential for the induction of this gene
Marsh et al., J Neurosci 2009
(Infarction, Middle Cerebral Artery...) :
TLR4 can
induce both
IFNbeta and interferon stimulated genes through its adapter molecule Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3
transcription factor
Watanabe et al., J Clin Invest 2010
(Helicobacter Infections) :
IRF7
induced IFN-beta production, which led to activation of a heterotrimeric
transcription factor complex known as IFN stimulated gene factor 3 ( ISGF3 ) and the subsequent production of CXCL10 and additional type I IFN
Fujita et al., Nature 1989
(Cell Transformation, Viral) :
Induction of endogenous IFN-alpha and
IFN-beta genes by a regulatory
transcription factor , IRF-1
Bluyssen et al., Proc Natl Acad Sci U S A 1995
:
Induction is due to activation of a multimeric
transcription factor , interferon stimulated gene factor 3 ( ISGF3 ), which is
activated by
IFN alpha/beta but not by IFN gamma