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IFNB1 — XAF1

Text-mined interactions from Literome

Micali et al., BMC cancer 2007 (Neoplasms) : In this report, we investigated the role of basal xaf1 promoter methylation in xaf1 expression and assessed the responsiveness of cancer cell lines to XAF1 induction by IFN-beta
Sun et al., Cancer Lett 2008 (Colonic Neoplasms) : The aim of this study is to determine the effect of IFNbeta on XAF1 expression and the putative mechanisms mediated by the critical role of signal transducers and activators of transcription 1 ( Stat1 ) ... Results showed that IFNbeta stimulated XAF1 promoter activity in colon cancer cell line DLD1 in a time- and dose dependent manner ... IFNbeta induced XAF1 expression was mediated by Stat1 through the interaction with ISRE-XAF1 ... Knocking down of the Stat1 expression and blocking its phosphorylation decreased IFNbeta induced XAF1 expression ... Results suggested that induction of an immediate early response gene-XAF1 by IFNbeta was mediated by the transcription regulator Stat1 through the ISRE site within the promoter region of XAF1 gene in colon cancer