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IRF4 — NFKB1

Pathways - manually collected, often from reviews:

• FastForward regulation: NFKB1 → IRF4 (transcriptional regulation, unknown) Lehtonen et al., Cytokine 2003*
  Evidence: DNABINDING
• FastForward regulation: NFKB1, RELA → IRF4 (transcriptional regulation, unknown) Lehtonen et al., Cytokine 2003*
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: IRF4 — NFKB1 (unknown, -) Lehtonen et al., J Immunol 2005*
• IRef Innatedb Interaction: IRF4 — NFKB1 (unknown, -) Sharma et al., J Immunol 2002*
• IRef Innatedb Interaction: IRF4 — NFKB1 (unknown, -) Saito et al., Cancer Cell 2007*
• IRef Innatedb Interaction: Complex of NFKB1-NFKB1-IRF4 (unknown, -) Sharma et al., J Immunol 2002*

Text-mined interactions from Literome

Xu et al., J Virol 2008 (Cell Transformation, Neoplastic) : The stimulation of IRF-4 by LMP-1 requires signaling from LMP-1 and involves cellular NF-kappaB
Cadera et al., J Exp Med 2009 : Because IRF4 is a target of NF-kappaB and is required for receptor editing, we suggest that NF-kappaB could be acting through IRF4 to regulate receptor editing
Cheng et al., J Interferon Cytokine Res 1998 : Therefore, effective ISRE activity of IP-10 VRE may require an IRF-like protein binding, which is enhanced by an NF-kappaB heterodimer binding to an adjacent KB site