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EGFR — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chen et al., Mol Cell Biol 2007
:
Basal
Rac1 activation is a direct
consequence of ligand independent increased
epidermal growth factor receptor (EGFR) phosphorylation in alpha1-null mesangial cells
Wu et al., Mol Med 2007
(Neoplasm Recurrence, Local...) :
Here we report that Rac1 is overexpressed in papilloma cells compared with normal laryngeal epithelial cells and that the increased levels of
Rac1 are
mediated by
EGFR activation
Dentelli et al., J Biol Chem 2007
(Diabetic Nephropathies...) :
Moreover, as shown by the expression of the dominant negative Rac-1 construct, we first report that ox-LDL mediated cell survival and cell cycle progression depend on
Rac-1 GTPase mediated reactive oxygen species production and on
epidermal growth factor receptor transactivation
Sarkar et al., Curr Biol 2007
:
We show that germ cells signal via the Egf class ligand Spitz ( Spi ) and provide evidence that the
Egfr associates with and acts through the guanine nucleotide exchange factor Vav to
regulate activities of
Rac1
Dise et al., Am J Physiol Gastrointest Liver Physiol 2008
:
Whereas EGF failed to activate Rac in colon cells from EGF receptor (EGFR) knockout mice, stable expression of wild-type
EGFR restored EGF stimulated
Rac activation and migration
Sosa et al., Mol Cell 2010
(Breast Neoplasms...) :
Moreover, we identified the GPCR CXCR4 as a crucial mediator of
P-Rex1/Rac1 activation in
response to
ErbB ligands
Norton et al., Antioxid Redox Signal 2013
(Anoxia) :
Consistent with these observations, CH increased KCl induced EGFR phosphorylation, and augmented depolarization induced
Rac1 activation in an
EGFR dependent manner ... Conclusion : CH augments membrane depolarization induced pulmonary VSM Ca ( 2+ ) sensitization and vasoconstriction through
EGFR dependent stimulation of
Rac1 and NOX 2
Lopez-Haber et al., Mol Pharmacol 2013
(Breast Neoplasms) :
Previous studies established that stimulation of
ErbB receptors in breast cancer cells
activates Rac1 and enhances motility via the Rac-guanine nucleotide exchange factor P-Rex1 ... As the Janus tyrosine kinase 2 (Jak2)/signal transducer and activator of transcription 3 ( Stat3 ) pathway has been shown to be functionally associated with ErbB receptors, we asked if this pathway could mediate
P-Rex1/Rac1 activation in
response to
ErbB ligands
Malliri et al., J Cell Biol 1998
:
Our data establish a novel link between AP-1 activity and
EGFR activation of
Rac and Rho, which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion