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RUNX1 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wolyniec et al., Oncogene 2009
:
In human fibroblasts, all effectors
induced p53 in the absence of detectable p14(Arf), whereas only
RUNX1-ETO induced senescence in p16(Ink4a)-null cells
Satoh et al., Leukemia 2012
(Leukemia, Myeloid, Acute...) :
As for this mechanism, we found that
RUNX1 directly regulates the transcription of GADD45A and that RUNX1 and
p53 synergistically
activate the GADD45A transcription
Masse et al., Cell death & disease 2012
:
It also showed that the regulation of
RUNX1 expression by dNp63 is
dependent on
p53 and that this coregulation relies on differential binding and activation of RUNX1 regulatory sequences by dNp63 and p53
Wu et al., J Biol Chem 2013
:
Indeed, forced expression of
RUNX1 stimulated the transcriptional activity of
p53 in response to ADR ... Taken together, our present results strongly suggest that
RUNX1 is
required for the stimulation of
p53 in response to DNA damage and also provide novel insight into understanding the molecular mechanisms behind p53 dependent DNA damage response