UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

IL22 — JAK1

Pathways - manually collected, often from reviews:

BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22/IL-22/IL-10R2C/TYK2 complex (IL22-IL10RA-TYK2) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-10R2C/TYK2 complex (IL22-IL10RA-TYK2) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) → STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B) (modification, activates)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22R1/JAK1 complex (IL22RA1-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22 (IL22) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22R1/JAK1 complex (IL22RA1-JAK1) → IL-22 (IL22) (modification, collaborate)

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis