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EPHB2 — GRK1

Text-mined interactions from Literome

Kurose et al., Nihon Yakurigaku Zasshi 1999 (Myocardial Reperfusion Injury) : Expression of GRK2-ct inhibited the H2O2 induced activation of ERK by 70 % and also inhibited the activation of Akt by 30 % ... In contrast with H2O2 induced activation of ERK , the activation of ERK induced by phorbol ester PMA and the activation of JNK and p38 induced by H2O2 were not affected by expression of GRK2-ct , indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit
Thakker et al., Neuropharmacology 2002 (Neuroblastoma) : Protein kinase C ( PKC ), but not ERK1/2 , inhibition blocked OFQ/N mediated GRK3 induction and mu and ORL1 receptor desensitization in BE ( 2 ) -C cells ... Here, we demonstrate for the first time a role for ERK1/2 mediated GRK2 induction in the development of tolerance to mu agonists, as well as cross-tolerance to OFQ/N ... We also demonstrate that chronic OFQ/N mediated desensitization of ORL1 and mu receptors occurs via cell-specific pathways, involving ERK1/2 dependent GRK2 , or PKC dependent and ERK1/2 independent GRK3 induction
Ren et al., Proc Natl Acad Sci U S A 2005 : GRK2 suppression actually increased beta-arrestin stimulated ERK activation
Gao et al., Acta Biochim Biophys Sin (Shanghai) 2005 (MAP Kinase Signaling System) : Western blotting assay shows that EGF induced ERK/MAPK phosphorylation increases 1.9-fold, 1.1-fold and 1.5-fold ( P < 0.05 ) at time point 30, 60 and 120 min, respectively when the cells were transfected with GRK2, suggesting the regulatory role of GRK2 on EGF induced ERK/MAPK activation
Jiménez-Sainz et al., Mol Biol Cell 2006 : This effect is independent of its role in receptor phosphorylation because the kinase-deficient mutant GRK2K220R was able to reduce this response, and ERK activation by CCR2BIX, a phosphorylation-defective receptor mutant, was also inhibited by GRK2 ... These results suggest an important role for GRK2 in the control of chemokine induction of ERK activation at the level of the MEK-ERK interface
Bessard et al., Hepatology 2006 : Inhibition of either MLCK or RhoK did not block ERK1/2 phosphorylation, whereas MLCK regulated ERK2 dependent p70S6K activation
Kara et al., Mol Endocrinol 2006 : In conclusion, we demonstrate the existence of a beta-arrestin dependent , GRK regulated mechanism for ERK activation by the FSH-R
Salim et al., FEBS Lett 2007 : Activation of the CRF ( 1 ) receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells
Kleibeuker et al., J Neurochem 2008 : Conversely, the 45 % decrease in GRK2 expression in astrocytes from GRK2+/- animals resulted in a more pronounced CCL2 induced ERK1/2 phosphorylation ... We found that GRK2 kinase activity was not required to decrease chemokine induced ERK1/2 phosphorylation, whereas regulation of CCL2 induced Akt phosphorylation did require an active GRK2 kinase domain
Lee et al., Br J Nutr 2010 : The extracellular signal regulated protein kinase 1/2 ( ERK1/2 ) -connexin 43 (Cx43) signalling pathway is crucial for the regulation of GJIC, and both GOK and GRK blocked the H2O2 induced phosphorylation of Cx43 and ERK1/2 in WB-F344 cells
Guo et al., PloS one 2011 : Silencing GRK2 or GRK3 expression caused a more sustained Ca ( 2+ ) mobilization, attenuated C3aR desensitization, and enhanced degranulation as well as ERK1/2 phosphorylation when compared to shRNA control cells
Liu et al., Nat Immunol 2012 : The extracellular signal regulated kinase Erk potentiated activity of the G protein coupled receptor kinase GRK2 and inhibited neutrophil migration, whereas the MAPK p38 acted as a noncanonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil migration by blocking GRK2 function
Zheng et al., Proc Natl Acad Sci U S A 2012 : By suppressing GRK expression with siRNA, we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation, whereas GRK2 inhibition increases ERK activation and partially inhibits AKT signaling
Zhang et al., J Biol Chem 2012 : We also found that nociceptin induced NOPR mediated JNK but not ERK signaling requires Ser-363, GRK3 , and Arrestin3