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EPHB2 — IL18
Text-mined interactions from Literome
Valledor et al., J Biol Chem 2000
:
Granulocyte/macrophage colony stimulating factor,
interleukin 3, and TPA, all of which induced macrophage proliferation, also
induced ERK activity, which was maximal at 5 min poststimulation
Morel et al., J Biol Chem 2002
(Arthritis, Rheumatoid...) :
Using phosphoinositide 3-kinase ( PI3-kinase ) inhibitor LY294002 and Src inhibitor PP2, we show that
interleukin (IL)-18 induced
ERK1/2 activation is Src kinase dependent ... Antisense ( AS ) c-Src oligonucleotide ( ODN ) treatment reduced
IL-18 induced
ERK1/2 expression by 32 % compared with control, suggesting an upstream role of Src in ERK1/2 activation
Maggi et al., J Biol Chem 2003
(Cardiovirus Infections...) :
ERK activation is
required for double stranded RNA- and virus induced
interleukin-1 expression by macrophages
MacGillivray et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
The protein tyrosine phosphatase SHP-2 regulates
interleukin-1 induced
ERK activation in fibroblasts
Chang et al., J Biol Chem 2004
(Inflammation...) :
The induction of prostaglandin E2 production,
interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially
regulated by
MEK/ERK activation
Wang et al., J Biol Chem 2005
:
SHP-2 modulates
interleukin-1 induced Ca2+ flux and
ERK activation via phosphorylation of phospholipase Cgamma1
Miranda et al., Leuk Res 2005
(MAP Kinase Signaling System) :
Additionally,
interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells, also
inhibited the ability of G-CSF to stimulate prolonged
MEK/ERK activation
Kanda et al., Eur J Immunol 2007
:
IL-18 induced phosphorylation of
ERK and Akt, while IFN-gamma induced phosphorylation of p38 MAPK
Iikura et al., Lab Invest 2007
:
However, IL-1beta,
IL-18 or IL-33
induced phosphorylation of
Erk , p38 and JNK in naïve HUCBMCs, and IL-33 or IL-1beta, but not IL-18, enhanced the survival of naive HUCBMCs and promoted their adhesion to fibronectin
Chandrasekar et al., J Biol Chem 2008
:
IL-18 induces ERK1/2 phosphorylation and enzyme activity, and pretreatment with the MEK inhibitor U0126, ERK1/2 inhibitor PD98059, or small interference RNA
targeted to
ERK1/2 attenuates ERK1/2 activation and NFATc4 phosphorylation
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Woolson et al., Cell Signal 2009
:
Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates
ERK1,2 activation in
response to either leptin or a soluble
interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate
Saraiva et al., Immunity 2009
:
Interleukin-10 production by Th1 cells requires
interleukin-12 induced STAT4 transcription factor and
ERK MAP kinase activation by high antigen dose
Ju et al., Eur J Immunol 2009
(Melanoma, Experimental) :
Activation of p38 MAP kinase, but not
ERK or JNK, by either TCR-stimuli or IL-12 and
IL-18 is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells, resulting in reduced production of IFN-gamma
Cuong et al., Life Sci 2009
(Inflammation...) :
Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha,
interleukin (IL)-6 , and IL-12 p40, and the
activation of
ERK1/2 and p38
Zhou et al., Int J Biochem Cell Biol 2013
:
Our data revealed that
IL-18 stimulated
ERK1/2 and NF-?B activation, improved p-Akt, p70 S6K and anti-apoptotic Bcl-2 levels, and deactivated phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) in NHEM
Lo et al., J Biol Chem 1998
:
Requirements of focal adhesions and calcium fluxes for
interleukin-1 induced
ERK kinase activation and c-fos expression in fibroblasts