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PGF — PTGS2

Text-mined interactions from Literome

Longo et al., Prostaglandins Leukot Essent Fatty Acids 1999 (Cholecystitis...) : Both LPS and LPC stimulated PGE2 and 6 keto PGF1alpha formation were blocked by COX-2 inhibitors in freshly isolated, normal human gallbladder mucosal cells and in the gallbladder cancer cells
Sautebin et al., Inflamm Res 1999 : These results demonstrate the role of COX-2 in the generation of 8-epi-PGF2alpha by LPS stimulated J774 macrophages
Lim et al., Lab Invest 2001 (Adenocarcinoma...) : COX-2 inhibitors suppressed cell proliferation and production of TXB2 and 6-keto-PGF1alpha , in a dose-dependant manner
Tsai et al., Mol Hum Reprod 2001 : On day 8, PGF ( 2alpha ) induced FP and PGHS-2 expression and at the same time decreased LH receptor expression, resulting in inhibition of progesterone output by GLC
Tsai et al., Reproduction 2001 : In contrast, PGF ( 2alpha ) significantly increased PGHS-2 mRNA expression in granulosa cells primed with forskolin for 7 or 10 days ... Granulosa cells become PGF ( 2alpha ) -responsive soon after expression of PGF(2alpha) receptor, whereas further differentiation is required before PGF ( 2alpha ) induces PGHS-2 mRNA upregulation
Wong et al., Atherosclerosis 2001 (Body Weight) : The highly selective COX-2 inhibitors rofecoxib and the furanone DFP at concentrations of up to 10 micromol/l had no effect on the arachidonic acid dependent production of 6-keto-PGF ( 1 alpha ), in contrast to indomethacin, which caused a complete inhibition at 0.5 micromol/l. Celecoxib caused a significant inhibition of 6-keto-PGF ( 1 alpha ) at 10 micromol/l but had little effect when the dose was lowered to 1 micromol/l. Similar effects of these inhibitors were observed with respect to the production of PGE ( 2 ) and no major difference was observed between aortic tissues from normal and cholesterol fed animals with regard to inhibitor sensitivity
Wu et al., Biol Reprod 2001 : There is positive feedback pathway in the ovine large luteal cell, such that prostaglandin ( PG ) F ( 2 alpha ) stimulation induces intraluteal PGF ( 2 alpha ) production as the result of induction of one of the rate limiting enzymes in PG production, cyclooxygenase-2 (Cox-2)
Schmeck et al., Inflammation 2003 : In contrast, Rho inhibition did not affect COX-2 dependent 6k-PGF ( 1alpha ) liberation when TcdB-10643 was added 10 h after LPS or TNFalpha stimulation of EC
Smedman et al., Clin Sci (Lond) 2004 : Neither the COX-2 inhibitor nor alpha-tocopherol had any effect on 8-iso-PGF2alpha levels after supplementation with CLA
Okuda et al., Biol Reprod 2004 : Moreover, a specific COX-2 inhibitor ( NS-398 ; 5 nM ) blocked the stimulatory effect of TNFalpha on PGF2alpha production ( P < 0.05 ) ... The overall results indicate that the stimulatory effect of TNFalpha on PGF2alpha production is mediated by the up-regulation of COX-2 gene expression and suggest that one of the mechanisms of the inhibitory effect of IFNtau on luteolysis is the inhibition of TNFalpha action in PGF2alpha production in the stromal cells by the down-regulation of COX-2 gene expression stimulated by TNFalpha
Kearney et al., J Am Coll Cardiol 2004 : The inhibition of COX-1 and COX-2 did not prevent the production of 8-epi PGF ( 2alpha ), suggesting that this is not enzymatically derived
Buerkle et al., Circulation 2004 (Thrombophilia) : Inhibition of Cox-2 reduced levels of 6-keto-PGF1alpha in vivo and in HUVEC supernatants ... Selective inhibition of Cox-2 reduces 6-keto-PGF ( 1alpha ) endothelial release, increases PVWIs, and increases firm platelet adhesion in hamster arterioles
Mandal et al., J Biol Chem 2005 (Inflammation) : Most importantly, uteroglobin inhibits FP-mediated NF-kappaB activation and cyclooxygenase-2 gene expression by binding and most likely by sequestering PGF2alpha into its central hydrophobic cavity, thereby preventing FP-PGF2alpha interaction and suppressing the production of inflammatory lipid mediators
Jabbour et al., Endocrinology 2005 (Adenocarcinoma...) : PGF2alpha-FP receptor activation rapidly induced COX-2 promoter, mRNA, and protein expression in FPS cells ... These effects of PGF2alpha on the expression of COX-2 could be abolished by treatment of FPS cells with an FP receptor antagonist ( AL8810 ) and chemical inhibitor of ERK1/2 kinase ( PD98059 ), or by inactivation of ERK1/2 signaling with dominant negative mutant isoforms of Ras or ERK1/2 kinase
Ishikawa et al., Endocrinology 2006 : IL-1beta regulated PGE ( 2 ) and PGF ( 2alpha ) production and cytokine expression require activation of cyclooxygenase-2 (COX-2) and c-Jun NH ( 2 ) -terminal kinase, as shown using specific enzyme inhibition
Edwards et al., Inflamm Bowel Dis 2006 (Disease Models, Animal...) : Gi alpha2-/- myofibroblasts from the small intestine and colon both released asymptotically equal to 50 % less arachidonate and 3- to 7-fold less PGE2 and 6-keto PGF1alpha in response to adenosine triphosphate, thrombin, tumor necrosis factor-alpha, or lipopolysaccharide, in a partially cyclooxygenase (COX)-2 dependent manner
Aisemberg et al., Proc Natl Acad Sci U S A 2007 (Fetal Resorption) : NO inhibited basal PGE and PGF ( 2alpha ) production in the decidua but activated their uterine synthesis and COX-II mRNA expression under septic conditions
Niswender et al., Society of Reproduction and Fertility supplement 2007 : PGF2alpha also activates COX-2 in large luteal cells which leads to secretion of PGF2alpha
Zerani et al., Reproduction 2007 : In day-4 CL, PGF2alpha induced an increase ( P < 0.01 ) in both COX-2 activity and PGF2alpha synthesis, whereas that of PGE2 remained unchanged ... In day-9 CL, PGF2alpha up-regulated ( P < 0.01 ) both COX-2 and PGE-9-K activities, and PGF2alpha production, but decreased ( P < 0.01 ) PGE2 synthesis
Song et al., J Biol Chem 2008 : Correspondingly, both PGDM and 2,3-dinor-11beta-PGF ( 2alpha ) were suppressed by inhibition of COX-1 and COX-2 , but not by selective inhibition of COX-2 in humans
Kim et al., Brain Res 2008 (Disease Models, Animal...) : In kainic acid induced seizures, the brain largely increases PGD ( 2 ), first from COX-1 and later COX-2 induced PGF ( 2alpha )
Sales et al., Mol Cell Endocrinol 2008 (Adenocarcinoma...) : In the present study, we investigated the effect of PGE ( 2 ) and PGF ( 2alpha ) on the expression of COX-2 via the FP receptor in endometrial adenocarcinoma cells stably expressing the FP receptor ( FPS cells )
Sena et al., Gen Comp Endocrinol 2008 : A non-selective COX inhibitor ( indomethacin ) and selective COX-2 inhibitor ( NS398 ) strongly inhibited the hCG- and P4-dependent production of PGF2*
Koeberle et al., Mol Cancer Ther 2009 : In lipopolysaccharide stimulated human whole blood, curcumin inhibited COX-2 derived PGE ( 2 ) formation from endogenous or from exogenous arachidonic acid, whereas the concomitant formation of COX-2 mediated 6-keto PGF ( 1 ) alpha and COX-1 derived 12 ( S ) -hydroxy-5-cis-8,10-trans-heptadecatrienoic acid was suppressed only at significant higher concentrations
Mbalaviele et al., Biochem Pharmacol 2010 (Arthritis, Rheumatoid) : In contrast, as expected, the selective COX-2 inhibitor, SC-236, inhibited PGE ( 2 ), PGF ( 1alpha ) and PGF ( 2alpha ) synthesis
Xiao et al., Am J Physiol Gastrointest Liver Physiol 2009 : A COX-1 inhibitor decreased and a COX-2 inhibitor increased PGF ( 2alpha ) levels ; GTPgammaS increased and GDPbetaS decreased the levels of PGF ( 2alpha )
Taniguchi et al., Reproduction 2010 : We further investigated the molecular mechanism by which PGF ( 2a ) stimulates PTGS2 expression ... Simultaneous administration of both superoxide dismutase and catalase to scavenge reactive oxygen species ( ROS ) inhibited the increases of nuclear NFKB p65 protein expression, lipid peroxide levels, and Ptgs2 mRNA expression induced by PGF ( 2a ) ... In conclusion, PGF ( 2a ) stimulates Ptgs2 mRNA expression and PGF ( 2a ) synthesis through NFKB activation via ROS in the corpus luteum of pseudopregnant rats
Brenneis et al., J Biol Chem 2011 (Disease Models, Animal...) : Interestingly, we found that activation of E-prostanoid ( EP ) 2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor ( IP ), thromboxane A(2) receptor ( TP ), PGD(2) receptor ( DP ), and PGF ( 2 ) receptor ( FP ), efficiently blocked LPS induced tumor necrosis factor a (TNFa) synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures
Ueno et al., FEBS J 2011 : Moreover, FP receptor mediated activation of the MEK/ERK cascade and COX-2 expression increased the production of PGF ( 2a ) and PGE ( 2 )
Ishida et al., Am J Physiol Heart Circ Physiol 2011 (Diabetes Mellitus, Type 2...) : In arteries from GK rats ( vs. those from Wistar rats ), 1 ) ATP- and UTP induced contractions, which were blocked by the nonselective P2 antagonist suramin, were enhanced, and these enhancements were suppressed by endothelial denudation, by cyclooxygenase (COX) inhibitors, or by a cytosolic phospholipase A ( 2 ) ( cPLA(2) ) inhibitor ; 2 ) both nucleotides induced increased release of PGE ( 2 ) and PGF ( 2a ) ; 3 ) nucleotide stimulated cPLA(2) phosphorylations were increased ; 4 ) COX-1 and COX-2 expressions were increased ; and 5 ) neither P2Y2 nor P2Y6 receptor expression differed, but P2Y4 receptor expression was decreased
Tian et al., Antioxid Redox Signal 2012 (Hypertension, Renovascular) : Five weeks of treatment with celecoxib or tempol reduced blood pressure, increased renal blood flow, and restored endothelial function in RHRs. Increased ROS production in RHR arteries was inhibited by ROS scavengers, but unaffected by COX-2 inhibitors ; whereas increased PGF ( 2a ) release was reduced by both ROS scavengers and COX-2 inhibitors
Shirasuna et al., Domest Anim Endocrinol 2012 : Silencing full-length PTGFR using small interfering RNA prevented PGF2a stimulated cyclooxygenase-2 ( PTGS2 ) mRNA induction ... By contrast, PGF2a could stimulate vascular endothelial growth factor A ( VEGFA ) mRNA even when full-length PTGFR was knocked down, thus suggesting that PGF2a may stimulate PTGS2 via full-length PTGFR, whereas VEGFA is stimulated via other PTGFR isoforms
Guo et al., Endocrinology 2012 : Cross talk between PKC and CREB in the induction of COX-2 by PGF2a in human amnion fibroblasts ... Although activation of PKC is known to induce COX-2 expression, it is not clear whether PGF2a can induce COX-2 via FP receptor coupled PKC activation ... PGF2a increased COX-2 expression and CREB1 phosphorylation, which could be blocked by either the FP receptor antagonist AL8810 or PKC inhibitor Ro31-7549 ... The induction of COX-2 by PGF2a and PMA could be attenuated by the small interfering RNA mediated knockdown of CREB1 expression or overexpressing dominant negative CREB1 ... A chromatin immunoprecipitation assay showed that the binding of CREB1 to the COX-2 promoter was increased by PGF2a and PMA in amnion fibroblasts ... In conclusion, we provide evidence that PGF2a induces COX-2 expression via the FP receptor and phosphorylates CREB1 by PKC, thus increasing CREB1 binding to the COX-2 promoter and the expression of COX-2 in human amnion fibroblasts
Xu et al., J Clin Endocrinol Metab 2013 : Indomethacin reversed the PGF2a induced effects on CX-43 and PTGS-2 , but it did not alter PGF2a induced PTGFR and OTR expression
Wu et al., Eur J Pharmacol 2013 : In addition, COX-2 was up-regulated by the treatment of 15- ( S ) -HETE and the increase of COX-2 expression participated in 15- ( S ) -HETE induced PLGF expression, which was confirmed by COX-2 shRNA or pharmacological COX-2 inhibitor
Bracken et al., Endocrinology 1997 : Steroid modulated, COX-2 dependent changes in PGF2 alpha secretion were observed
Zingarelli et al., Br J Pharmacol 1997 : In comparative experiments indomethacin, a non selective COX inhibitor, and NS-398, a selective COX-2 inhibitor, reduced ( LPS ) stimulated 6-keto-PGF1alpha production in J774 macrophages in a dose dependent manner without affecting nitrite release
Tsai et al., Biol Reprod 1997 : PGHS-2 protein was induced by all three treatments 4-12 h later, and accumulation of PGF2alpha in the culture media increased at 12 and 24 h posttreatment