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EPHB2 — GPER1
Text-mined interactions from Literome
Ahola et al., Eur J Biochem 2002
(Breast Neoplasms) :
The regulation of
GPR30 was
independent of
ERK pathway activation, but the p38 pathway inhibitor induced GPR30 expression, which suggested a potential gene regulation pathway
Ahola et al., Endocrinology 2002
(Breast Neoplasms) :
Transient expression of
GPR30 decreased ERK-1 and -2 activity ; and in the cells in which GPR30 expression was decreased by the antisense,
ERK activities were
increased
Maggiolini et al., J Biol Chem 2004
(Breast Neoplasms) :
GPR30 dependent activation of
ERK1/2 by E2 and phytoestrogens occurs via a Gbetagamma associated pertussis toxin-sensitive pathway that requires both Src related and EGF receptor tyrosine kinase activities
Park et al., Endocrinology 2009
(Prostatic Hyperplasia) :
In normal cells, we found that a nongenomic, rapid E2 signaling pathway is predominantly involved, mediated by
G protein coupled receptor-30 and the subsequent
activation of
ERK1/2
Ding et al., Am J Physiol Cell Physiol 2009
:
Estradiol mediated
ERK phosphorylation and apoptosis in vascular smooth muscle cells
requires GPR 30
Recchia et al., J Biol Chem 2011
(Breast Neoplasms...) :
Moreover, we show that HIF-1a-responsive elements located within the promoter region of GPER are involved in hypoxia dependent transcription of
GPER , which
requires the ROS induced activation of
EGFR/ERK signaling in both SkBr3 and HL-1 and cells
Sharma et al., Endocrinology 2011
:
GPER is expressed in MIN6 cells, where estradiol and the
GPER-selective agonist G-1 mediate calcium mobilization and
activation of
ERK and phosphatidylinositol 3-kinase ... Our results indicate that
GPER activation of the epidermal growth factor receptor and
ERK in response to estradiol treatment plays a critical role in the secretion of insulin from ß-cells
Lappano et al., Breast Cancer Res 2012
(Breast Neoplasms...) :
Moreover,
GPER was
required for epidermal growth factor receptor (EGFR) and
ERK activation by EGF as ascertained by using MIBE and performing gene silencing experiments