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PARP1 — PCNA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PCNA — PARP1 (direct interaction, pull down) Sekimoto et al., Mol Cell 2010*
• IRef Biogrid Interaction: PCNA — PARP1 (physical association, affinity chromatography technology) Frouin et al., J Biol Chem 2003*
• IRef Biogrid Interaction: PCNA — PARP1 (direct interaction, pull down) Cazzalini et al., DNA repair 2010*
• IRef Biogrid Interaction: PCNA — PARP1 (physical association, affinity chromatography technology) Cazzalini et al., DNA repair 2010*
• IRef Biogrid Interaction: PCNA — PARP1 (physical association, affinity chromatography technology) Lee et al., Molecular cancer 2010*
• IRef Biogrid Interaction: PCNA — PARP1 (direct interaction, pull down) Pozo et al., Mol Cell Biol 2011*
• IRef Hprd Interaction: PCNA — PARP1 (in vivo) Frouin et al., J Biol Chem 2003*
• IRef Intact Interaction: Complex of 46 proteins (association, anti tag coimmunoprecipitation) Abramson et al., Cell 2010
• IRef Intact Interaction: Complex of 306 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Ophid Interaction: PCNA — PARP1 (aggregation, confirmational text mining) Frouin et al., J Biol Chem 2003*
• IRef Ophid Interaction: PCNA — PARP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lau et al., Cancer Biol Ther 2007 (Carcinoma, Hepatocellular...) : In the in vivo setting, YC-1 combined with cisplatin remarkably suppressed tumor growth in a HCC xenograft model, and this effect was also accompanied by YC-1 mediated downregulation of P-Stat3 ( 705 ), Bcl-xL, Cyclin D1 and survivin, and induction of cleaved caspase 9 and PARP in the tumor tissues
Liu et al., BMC cancer 2010 (Brain Neoplasms...) : Changes in several cell cycle regulators such as Cyclins D1 and E, PCNA and Ki67, and several apoptosis related regulators such as p53, p-JNK, p-AKT, and PARP were determined by Western blot analysis
Zhang et al., PloS one 2012 : It is possible that the elevated cAMP levels inhibit growth and induce apoptosis in Hela cells through induction of p21 and cleaved caspase-3/PARP-1 expression, and causing down-regulation of PCNA and cell cycle arrest with accumulation of cells in the G0/G1 and G2/M fractions