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PGD — PTGS2

Text-mined interactions from Literome

Fujishima et al., Proc Natl Acad Sci U S A 1999 : Whereas cPLA2 is essential for immediate eicosanoid generation by providing arachidonic acid, its role in delayed-phase PGD2 generation is more complex and involves the activation dependent induction of prostaglandin endoperoxide synthase 2 and the supply of arachidonic acid for metabolism to PGD2
Tanaka et al., Biol Pharm Bull 1999 : These results suggest that both AA- and EPA-treatment inhibit PGD2 synthesis by inactivating PGHS-2 without affecting induction of the protein, and that the increase or decrease in AA content following AA- or EPA-treatment correlates simply with the level of AA release but not with that of PGD2 formation
Inoue et al., J Biol Chem 2000 : A selective COX-2 inhibitor, NS-398, inhibits production of PGD ( 2 ) in the U937 cells
Fernández-Tome et al., Biochem Pharmacol 2004 : COX-2 mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue
Dore-Duffy et al., Microvasc Res 2005 : Hypoxia induced release of PGD2/PGJ2 was COX-1 dependent and did not involve COX-2
Kämpfer et al., Diabetes 2005 (Diabetes Mellitus, Type 2...) : COX-2 expression did not significantly contribute to PGE2/PGD2 production in impaired wound tissue
Diaz et al., Biochim Biophys Acta 2006 : Delayed-phase PGD ( 2 ) generation and COX-2 induction were reduced approximately 35 % in C57BL/6 Pla2g5-/- BMMC and were restored by exogenous PGE ( 2 )
Cao et al., Anal Biochem 2008 : This direct comparison showed that COX-2 gene expression can lead to differential production of PGD ( 2 ) and PGE ( 2 ) by epithelial cells and macrophages
Grill et al., J Neurochem 2008 : It can be assumed, that PGD2 biosynthesis under control conditions is mediated via COX-1 and that during inflammation, increased PGD2 is dependent on COX-2
Shiraishi et al., J Immunol 2008 (Respiratory Hypersensitivity) : These changes were associated with induction of cyclooxygenase-2 (COX-2) expression and COX-2 dependent PGD2 synthesis in the lungs, particularly in alveolar macrophages ... Our data demonstrate that COX-2 dependent production of PGD2 followed by eosinophil recruitment into the airways via a CRTH2 receptor are the major pathogenetic factors responsible for the dsRNA induced enhancement of airway inflammation and responsiveness
Moon et al., Free Radic Biol Med 2008 : Exogenous NO augmented COX-2 protein expression and increased COX-2 dependent PGD ( 2 ) generation in response to SCF, IL-10, and IL-1beta, or antigen activation in combination with IL-10 and IL-1beta after sensitization with IgE ... These results show that exogenous NO can increase COX-2 dependent PGD ( 2 ) and IL-6 production by MC in inflammatory environments through the p38 MAPK pathway
Ueno et al., Biochim Biophys Acta 2008 : Ectopic expression of NLRP3 in BMMCs resulted in marked attenuation of cyclooxygenase (COX)-2 dependent delayed PGD ( 2 ) generation, whereas it had no effects on other effector functions, including degranulation, COX-1 dependent immediate PGD ( 2 ) generation and cytokine/chemokine expression ... Our results suggest that, in mouse mast cells, NLRP3 counter-regulates COX-2 dependent sustained production of PGD ( 2 ), a prostanoid that exhibits both pro- and anti-allergic effects, thereby potentially influencing the duration of allergic and other mast cell associated inflammatory diseases
Fujimori et al., Gene 2008 : Moreover, NS-398, a COX-2 inhibitor and AT-56, an L-PGDS inhibitor, suppressed PGD ( 2 ) production in TE671 cells cultured under the serum starved condition ... These results indicate that PGD ( 2 ) production stimulated by serum starvation is mediated by both COX-2 and L-PGDS through enhancement of USF1 in TE671 cells
Kolaczkowska et al., Immunology 2009 (Peritonitis) : Application of selective COX inhibitors revealed enhanced COX-1 dependent PGE ( 2 ) production and impaired COX-2 dependent PGD ( 2 ) synthesis in MMP-9 ( -/- ) mice ... In non-transgenic mice, however, inflammatory leucocytes die apoptotically in the late stages of peritonitis as a result of COX-2 dependent PGD ( 2 ) activity
Lin et al., Vet Immunol Immunopathol 2010 : The mixed COX-1/COX-2 inhibitor piroxicam blocked PGD2 and PGE2 production, but upregulated LTC4 following treatment while tepoxilan ( Zubrin ), a pan COX/LOX inhibitor, markedly reduced the production of all eicosanoids
Brenneis et al., J Biol Chem 2011 (Disease Models, Animal...) : Interestingly, we found that activation of E-prostanoid ( EP ) 2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor ( IP ), thromboxane A(2) receptor ( TP ), PGD(2) receptor ( DP ), and PGF ( 2 ) receptor ( FP ), efficiently blocked LPS induced tumor necrosis factor a (TNFa) synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures
de Oliveira et al., Journal of neuroinflammation 2012 : Interestingly, NVP-BEZ235, a dual PI3K/mTOR inhibitor, enhanced COX-2 and reduced mPGES-1 immunoreactivity, albeit PGE2 and PGD2 levels were enhanced in LPS stimulated microglia
Lu et al., Food Chem Toxicol 2013 : The purpose of this study is to investigate the effects of n-hexane extracts from bones and internal organs of Japanese eel, Anguilla japonica ( HEE ), on cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) generation in stem cell factor (SCF), IL-10, plus LPS induced mouse bone marrow derived mast cells ( BMMCs ) and on passive cutaneous anaphylaxis ( PCA ) in mice
Lu et al., Biol Pharm Bull 2013 : The authors investigated the effect of manassantin B ( Man B ) isolated from Saururus chinensis ( S. chinensis ) on cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) generation in mouse bone marrow derived-mast cells ( BMMCs ) ... Man B inhibited the generation of PGD2 dose-dependently by inhibiting COX-2 expression in immunoglobulin E ( IgE ) /Ag stimulated BMMCs ... Taken together, the present results suggest that Man B suppresses COX-2 dependent PGD2 generation by primarily inhibiting Fyn kinase in FceRI mediated mast cells
Murakami et al., J Biol Chem 1994 : In contrast, induction of PGHS-2 did not mediate an increase in PGD2 generation in response to stimulation with IgE and antigen
Bingham et al., J Biol Chem 1996 : PGHS-2 dependent delayed-phase PGD2 generation elicited by IgE dependent activation of BALB/cJ BMMC primed with KL + IL-10 was also accompanied by the induction of type IIA PLA2 transcripts and was suppressed by heparin, with concomitant release of PLA2 into the supernatant
Ashraf et al., Biochem Biophys Res Commun 1996 : These results suggest that, of the three PLA2s expressed in BMMC, type II sPLA2 is the critical enzyme that is coupled with COX-2 dependent PGD2 generation elicited by IgE/Ag in the presence of IL-10 + IL-1beta
Matsumoto et al., Biochem Biophys Res Commun 1997 : Pharmacological studies showed that formation of PGE2 was mediated predominantly by COX-2, PGD2 by COX-1, and TXB2 by both COX-1 and COX-2 depending upon the timing of LPS stimulation