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CD28 — RAC1

Pathways - manually collected, often from reviews:

• Reactome Reaction: CD28 → RAC1 (reaction) Crespo et al., Nature 1997, Han et al., Science 1998

Text-mined interactions from Literome

Tiede et al., J Clin Invest 2003 : CD28 dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
Cook et al., J Biol Chem 2003 : CD28 dependent activation of HIV-1 transcription also required the GTPase activity of Rac1 , which was not activated during costimulation with the mutated receptor
Müller et al., Traffic 2006 : Consistent with their inability to activate Cdc42 and Rac1 in response to the ligation of CD3/CD28 , T cells exposed to MV fail to acquire a morphology consistent with spreading and lamellopodia formation
Wang et al., Transpl Immunol 2007 : Vav1-Rac signaling plays a pivotal role in TCR/antigen and CD28 signals for T cell activation