◀ Back to RAC1

RAC1 — SERPINE1

Text-mined interactions from Literome

Diebold et al., Thromb Haemost 2008 : Expression of dominant negative Rac-1 ( RacT17N ) prevented thrombin induced PAI-1 expression whereas constitutively active RacG12V enhanced PAI-1 levels ... Finally, upregulation of PAI-1 by Rac-1 and HIF-1 was essential for thrombin stimulated proliferation of PASMC
Ando et al., J Atheroscler Thromb 2011 : Inhibition of RhoA attenuated thrombin triggered [ Ca ( 2+ ) ] ( i ) increase and TF and PAI-1 expression in HAECs, whereas thrombin triggered ROS generation and TF and PAI-1 expression were blocked by inhibition of Rac1
Petry et al., Thromb Haemost 2012 : Thus, our findings show that capillary formation induced by thrombin via Rac1 dependent activation of HIF-1 and PAI-1 is limited by the concomitant release of NO which reduced ROS bioavailability