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MSC — TLR4
Text-mined interactions from Literome
Romieu-Mourez et al., J Immunol 2009
(Inflammation) :
We observed that human
MSC and macrophages expressed TLR3 and TLR4 at comparable levels and
TLR mediated activation of MSC
resulted in the production of inflammatory mediators such as IL-1beta, IL-6, IL-8/CXCL8, and CCL5 ... Hence,
TLR activated
MSC are capable of recruiting immune inflammatory cells
Wang et al., PloS one 2010
(Reperfusion Injury) :
TLR4 inhibits
mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC mediated cardioprotection
Cassatella et al., Stem Cells 2011
:
In this study, we aimed to assess whether Toll-like receptor-3 (TLR3)- and
TLR4 activated
BM-MSC influence human neutrophil ( PMN ) responses under coculture conditions ... Finally, the effects exerted by TLR3- or
TLR4 stimulated
BM-MSC on PMN are conserved even after the previous priming of BM-MSC with IFN-? and tumor necrosis factor-a
Raicevic et al., Tissue Eng Part A 2012
:
TLR3 or
TLR4 triggering
increased the osteogenesis in AT- and, to lesser extent, in
BM-MSC