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CXCL12 — NAMPT
Text-mined interactions from Literome
Kanda et al., Endocrinology 2011
(Psoriasis) :
Visfatin enhances
CXCL8 , CXCL10, and CCL20 production in human keratinocytes ...
Visfatin enhanced TNF-a induced CXC chemokine ligand ( CXCL ) 8,
CXCL10 , and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective ... A small interfering RNA against nuclear factor-?B ( NF-?B ) p65 suppressed the
visfatin induced production of
CXCL8 , CXCL10, and CCL20 whereas a small interfering RNA against signal transducer and activator of transcription ( STAT ) 3 suppressed CXCL8 induction ... These results suggest that
visfatin enhances
CXCL8 , CXCL10, and CCL20 production in human keratinocytes and homologous chemokine production in murine skin
Huang et al., J Cell Physiol 2013
(Colorectal Neoplasms...) :
Visfatin induces
stromal cell derived factor-1 expression by ß1 integrin signaling in colorectal cancer cells ... We found that
visfatin stimulation
led to an increase in the expression and secretion of
SDF-1 in CRC DLD-1 and SW48 cells ... Experiments involving specific inhibitors and small interfering RNA demonstrated that the activation of ERK and p38 mitogen activated protein kinase ( MAPK ) pathways are critical for
visfatin induced
SDF-1 expression ... Inhibition of NF-?B and AP-1 activation blocked the
visfatin induced expression and activity of the
SDF-1 promoter ... The
effect of
visfatin on DLD-1 signaling and
SDF-1 expression was mediated by ß1 integrin