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IL1B — PI3

Text-mined interactions from Literome

Ojaniemi et al., Eur J Immunol 2003 : The induction of IL-1beta , but not of MIP-2 or TNF-alpha, was blocked by the PI 3-kinase inhibitors LY294002 and wortmannin
Lee et al., J Biol Chem 2004 (Inflammation) : IL-1 beta activated phosphatidylinositol (PI) 3-kinase , the enzyme activity of which was greatly stimulated after a 5-min exposure to IL-1 beta
Gong et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2004 : Among the inhibitors of intracellular signaling transduction pathways, mitogen activated protein kinases ( MAPK ) inhibitor PD98059 ( 40 micromol/L ) and p38 MAPK inhibitor SB203580 ( 5 micromol/L ) completely blocked the stimulatory effect of IL-1beta, and phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 ( 10 micromol/L ) partly blocked the induction of IL-1beta
Lajaunias et al., Eur J Immunol 2005 (Inflammation) : Finally, inhibition of phosphoinositide 3-kinase (PI3K) dramatically enhanced the IL-1 beta response to anti-CD33 and neuraminidase, while inhibition of p38 mitogen activated protein kinase ( MAPK ) abolished it
Solà-Villà et al., Kidney Int 2006 : SB 203580, a p38 mitogen activated protein kinase inhibitor, weakly inhibited the induction of VEGF by IL-1beta in a concentration dependent manner, whereas LY 294002, a phosphoinoside 3-kinase (PI3-K) inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, strongly inhibited both IL-1beta- and tumor necrosis factor-alpha induced VEGF formation in a concentration dependent manner
Molnarfi et al., J Immunol 2007 : In contrast, PI3K inhibition increased the production of IL-1beta protein in both CE ( sHUT ) - and LPS activated monocytes, the enhancement being drastically higher in the former ... This was not due to changes in IL-1beta mRNA steady-state levels or transcript stability, but to the involvement of PI3Ks in the repression of IL-1beta secretion ... The present results demonstrate that PI3Ks are involved in the inhibition of IL-1beta secretion and in the induction of sIL-1Ra production in human blood monocytes by controlling different mechanisms in conditions mimicking chronic/sterile ( CE ( sHUT ) ) and acute/infectious ( LPS ) inflammation
Wrann et al., J Immunol 2007 (Sepsis) : In addition, PI3K inhibition resulted in strongly elevated TLR-4 mediated generation of IL-1beta and IL-8 in neutrophils when these cells were co-stimulated with C5a
Molnarfi et al., Mol Immunol 2008 (Acute Disease...) : We previously demonstrated that PI3Ks regulate differential production of IL-1beta and its specific inhibitor secreted IL-1 receptor antagonist ( sIL-1Ra ) by human monocytes
Donaldson et al., Biochem Biophys Res Commun 1996 : Interleukin-1 beta activates PI 3-kinase in renal mesangial cells ... These experiments suggest that IL-1 beta can activate PI 3-kinase in renal mesangial cells and that the enzyme plays a role in IL-1 beta induced PGE2 and NO formation in the renal mesangial cell