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ANXA6 — PTBP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mosca et al., Blood 2000
:
Phenotypically mature
DCs could be
induced to produce high levels of IL-12
p70 only when provided 2 simultaneous stimulatory signals
Kandil et al., Clin Exp Immunol 2005
(Necrosis) :
Furthermore, priming
DCs with necrotic cells
augmented IL-12p70 secretion significantly in conjunction with CD40 cross linking
Jongmans et al., J Immunother 2005
(Inflammation) :
No
IL-12p70 could be
detected when
DCs were stimulated with TNF-alpha/PGE2 combined with MCM or IL-1beta/IL-6, presumably by suppression by PGE2
Tada et al., Infect Immun 2005
:
The stimulation of
DCs with MDP and FK565 in combination with lipid A, poly ( I:C ), and CpG DNA, but not with Pam3CSSNA, synergistically
induced interleukin-12 (IL-12)
p70 and gamma interferon ( IFN-gamma ), but not IL-18, in culture supernatants and induced IL-15 on the cell surface
Trepiakas et al., Vaccine 2008
(Neoplasms) :
This DC maturation cocktail was described to fulfill the criteria for optimal DC generation and to be superior to the standard DC ( sDC ) cocktail as it
induced fully mature
DCs with potent
IL-12p70 secretion together with CCR7 expression which is necessary for priming of a TH1 response and for migration to the draining lymph node, respectively
Liu et al., Zhonghua Er Ke Za Zhi 2008
:
( 1 ) By up-regulating splenic CD8alpha ( + )
DCs and
inducing IL-12p70 and IL-10 production in BALB/c mice, neonatal BCG vaccination promoted Th1/Tr1 development
Charoensap et al., Trans R Soc Trop Med Hyg 2008
(Melioidosis) :
We also found that, although the LPS mutant could readily activate monocyte derived human
DCs , it
induced lower levels of
IL-12p70 and IL-10 production than its wild-type counterpart ( P < 0.01 )
Ceballos et al., J Exp Med 2009
:
Interaction of spermatozoa with
DCs not only leads to the transmission of HIV-1 and the internalization of the spermatozoa but also
results in the phenotypic maturation of DCs and the production of IL-10 but not
IL-12p70
Marin-Esteban et al., J Immunother 2010
(Neoplasms) :
LPS stimulation of
DCs induced IL-10,
IL-12p70 , TNFalpha and IL-1beta secretion, and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion
Kubota et al., Scand J Immunol 2010
(Staphylococcal Infections) :
However, a number of reports have shown that bacterial stimuli are unable to
induce macrophages and/or
DCs to produce sufficient amounts of
IL-12p70 unless these cells are primed by IFN-gamma
Kono et al., Vaccine 2012
(Listeriosis) :
However, it has been reported that standard fully mature
DCs show
reduced ability to produce
IL-12p70 upon subsequent interaction with antigen ( Ag ) -specific T cells, limiting their in vivo performance for vaccines
Lewkowich et al., Mucosal Immunol 2013
:
Decreased AHR was associated with enhanced serum interleukin (IL)-12 p40, and in vitro stimulation of
DCs with allergen and PD-L2-Fc
reduced IL-12
p70 production, suggesting that PD-L2 inhibits allergen-driven IL-12 production
Sharma et al., Mol Cell Biol 1997
:
In both cell types, overexpression of either the
PTB or the SAIN protein
caused a significant decrease in insulin induced tyrosine phosphorylation of IRS-1 and Shc proteins, IRS-1 associated phosphatidylinositol 3-kinase (PI 3-K) enzymatic activity,
p70s6k activation, and p44 and p42 mitogen activated protein kinase ( MAPK ) phosphorylation ... p70s6k is a downstream target of PI 3-K, and insulin stimulated
p70s6k was
inhibited by
PTB or SAIN expression