Gene interactions and pathways from curated databases and text-mining

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TNFRSF1A — TRADD

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zheng et al., Mol Cell Biol 2006 : We found that TRADD is required for TNFR1 to induce NF-kappaB activation and caspase-8 dependent apoptosis but is dispensable for TNFR1 initiated, RIP1 dependent necrosis
Pobezinskaya et al., Nat Immunol 2008 : TRADD was essential for TNFR1 signaling in mouse embryonic fibroblasts but was partially dispensable in macrophages ; abundant expression of the adaptor RIP in macrophages may have allowed some transmission of TNFR1 signals in the absence of TRADD
Kieser et al., Biol Chem 2008 : TRADD mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase dependent apoptosis