◀ Back to SREBF1
NFYA — SREBF1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
SREBF1
→
NFYA
(indirect_complex)
Xiong et al., Proc Natl Acad Sci U S A 2000*, Amemiya-Kudo et al., J Lipid Res 2002*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Schiavoni et al., Biochim Biophys Acta 2010*, Ishimoto et al., Biochem J 2010*, Harada et al., Biochem Biophys Res Commun 2012*, Bennett et al., J Biol Chem 1995*, Ericsson et al., J Biol Chem 1996*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998
-
Reactome Reaction:
NFYA
→
SREBF1
(reaction)
Xiong et al., Proc Natl Acad Sci U S A 2000*, Nagai et al., Biochem Biophys Res Commun 2002*, Amemiya-Kudo et al., J Lipid Res 2002*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Schiavoni et al., Biochim Biophys Acta 2010*, Ishimoto et al., Biochem J 2010*, Harada et al., Biochem Biophys Res Commun 2012*, Bennett et al., J Biol Chem 1995*, Vallett et al., J Biol Chem 1996*, Ericsson et al., J Biol Chem 1996*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998
-
Reactome Reaction:
SREBF1
→
NFYA
(reaction)
Xiong et al., Proc Natl Acad Sci U S A 2000*, Amemiya-Kudo et al., J Lipid Res 2002*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Schiavoni et al., Biochim Biophys Acta 2010*, Ishimoto et al., Biochem J 2010*, Harada et al., Biochem Biophys Res Commun 2012*, Bennett et al., J Biol Chem 1995*, Ericsson et al., J Biol Chem 1996*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998
-
Reactome Reaction:
NFYA
→
SREBF1
(indirect_complex)
Xiong et al., Proc Natl Acad Sci U S A 2000*, Nagai et al., Biochem Biophys Res Commun 2002*, Amemiya-Kudo et al., J Lipid Res 2002*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Schiavoni et al., Biochim Biophys Acta 2010*, Ishimoto et al., Biochem J 2010*, Harada et al., Biochem Biophys Res Commun 2012*, Bennett et al., J Biol Chem 1995*, Vallett et al., J Biol Chem 1996*, Ericsson et al., J Biol Chem 1996*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998
Text-mined interactions from Literome
Nackley et al., Endocrinology 2002
:
YY1 inhibited SREBP-1a/nuclear factor Y (NF-Y) enhancement of StAR activation and YY1 decreased
SREBP-1a binding to a sterol regulatory element in the
presence or absence of
NF-Y
Damiano et al., Biochem J 2009
:
Our data show that PUFA inhibition of hepatic Cic gene transcription is mediated not only by the nuclear level of
SREBP-1c , but also might
involve a reduction in Sp1 and
NF-Y DNA binding, suggesting differential mechanisms in the Cic gene regulation by different PUFA
Ericsson et al., J Biol Chem 1996
:
We now demonstrate that the binding of recombinant
SREBP-1 to its cognate site ( SRE-3 ) within the FPP synthase promoter in vitro is
enhanced by binding of
NF-Y to the upstream inverted CCAAT box ... In contrast,
NF-Y does not
stimulate the binding of
SREBP-1 to SRE-3 when the inverted CCAAT box is either mutated or 4 base pairs ( bp ) are inserted between the inverted CCAAT box and SRE-3 ... These studies suggest that the binding of
SREBP-1 to SRE-3 in the FPP synthase promoter, and subsequent stimulation of transcription, is
dependent on synergistic binding and a functional interaction between SREBP-1 and
NF-Y
Jackson et al., J Lipid Res 1998
:
Gel mobility shift assays demonstrated that the synergistic binding of
SREBP-1a to SRE-3 was
dependent on the binding of recombinant
nuclear factor Y (NF-Y) to the DNA, consistent with the in vivo regulation studies