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GSK3B — PRKCA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kirshenboim et al., J Mol Neurosci 2004
:
Lithium mediated phosphorylation of
glycogen synthase kinase-3beta involves PI3 kinase dependent activation of
protein kinase C-alpha
Wang et al., Neoplasia (New York, N.Y.) 2006
(Colonic Neoplasms) :
The effect of NT was blocked by inhibitors of protein kinase C ( PKC ), but not by inhibitors of MEK1 or phosphatidylinositol-3 kinase, suggesting a predominant role for PKC in GSK-3beta phosphorylation by NT. Pretreatment with Gö6976 ( which inhibits PKCalpha and PKCbeta1 ) or downregulation of endogenous
PKCalpha or PKCbeta1
blocked NT-mediated
GSK-3beta ( but not GSK-3alpha ) phosphorylation
Johnson et al., Am J Physiol Lung Cell Mol Physiol 2009
:
First, to assess the
role of
PKCalpha in the phosphorylation of
GSK3beta ( i.e., an indicator of GSK3beta inhibition ), PMEC were pretreated with 1 ) nonsense-RNA-PKCalpha, 2 ) siRNA-PKCalpha, and 3 ) the PKC inhibitor Gö6983 ... The data indicate that TNF induces endothelial activation that is modulated by a
PKCalpha dependent inhibition of
GSK3beta