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BCL6 — CXCR5

Text-mined interactions from Literome

Yu et al., Immunity 2009 : Here, we showed that Bcl-6 directs Tfh cell differentiation : Bcl-6-deficient T cells failed to develop into Tfh cells and could not sustain germinal center responses, whereas forced expression of Bcl-6 in CD4 ( + ) T cells promoted expression of the hallmark Tfh cell molecules CXCR5 , CXCR4, and PD-1
Choi et al., Immunity 2011 : We demonstrate that inducible costimulator (ICOS) provides a critical early signal to induce the transcription factor Bcl6, and Bcl6 then induces CXCR5 , the canonical feature of Tfh cells
Diehl et al., Immunol Cell Biol 2012 : However, retroviral overexpression of BCL6 in total human CD4 ( + ) T cells only transiently increased CXCR5 , the canonical T ( FH ) -defining surface marker
Liu et al., Immunol Rev 2013 : During Tfh cell ontogeny, increased CXCR5 expression directs activated T-cell migration to the follicles, and their interaction with B cells leads to Bcl6 upregulation, which helps establish effector and memory Tfh cell program