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CD4 — RPL17

Text-mined interactions from Literome

Izawa et al., J Immunol 2007 : CD8 ( + ) PD1 ( + ) T cells suppress alloreactive CD4 ( + ) T cells but do not inhibit the functions by alloreactive CD8 ( + ) T cells in vitro
D'Souza et al., J Immunol 2007 (Chronic Disease...) : To investigate the role of PD-1 in HIV associated CD4 ( + ) T cell dysfunction, we measured PD-1 expression on blood and lymph node T cells from HIV infected subjects with chronic disease
Moorman et al., Vaccine 2011 (Hepatitis C, Chronic) : These results suggest that PD-1 signaling may be involved in impairing CD4 ( + ) T cell responses to HBV vaccination in subjects with HCV infection, and raise the possibility that blocking this negative signaling pathway might improve success rates of immunization in the setting of chronic viral infection
Qiao et al., Clin Immunol 2012 (Colitis) : In this study, we show that loss of PD-1 does not lead to defective induction of CD4 ( + ) T cell anergy in vitro and in vivo
Pauken et al., Diabetes 2013 (Diabetes Mellitus, Type 1) : These data support a model by which PD-1 regulates islet-reactive CD4 ( + ) T cells in a cell intrinsic manner by suppressing proliferation, inhibiting infiltration of the pancreas, and limiting diabetes
Li et al., Retrovirology 2013 : Increased CXCR5 and PD-1 expression was blocked by soluble CD4 or specific inhibitors of the Akt kinase, showing a direct relationship between CD4 signaling, T cell activation and Fas dependent cell death ... The same inhibitor, antibodies blocking the CD4 binding site on gp120, or soluble CD4 also prevented the increase in expression of CXCR5 or PD-1 , and reduced the levels of Fas dependent cell death