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LRP6 — TCF3
Text-mined interactions from Literome
Mi et al., J Cell Biochem 2005
:
In the absence of exogenous Wnt 3a, full-length ( FL )
LRP6 , but not LRP5,
increased TCF/LEF-1 transcriptional activity, however both significantly potentiated Wnt 3a-induced
TCF/LEF-1 activation
Bhat et al., Gene 2007
:
In the presence of Wnt1,
LRP5 or the HBM variant ( LRP5-G171V ) induces beta-catenin nuclear translocation and
activates T cell factor ( TCF ) -luciferase reporter activity
Mi et al., J Neurochem 2007
:
Interestingly,
LRP6 which lacks its extracellular domain can constitutively
activate TCF/LEF and potentiate the Wnt signal
Beagle et al., PloS one 2010
:
LRP6-ICD interacts with AES exclusively in the nucleus and
represses AES mediated
TCF/LEF-1 reporter transcription