Cheng et al., Free Radic Biol Med 2009
:
These results suggest that in HTSMCs, CSE induced NADPH oxidase activation leading to phosphorylation of p42/p44 MAPK, p38 MAPK, and JNK
Shih et al., J Cell Physiol 2010
:
CSE activated NADPH oxidase through c-Src in bEnd.3 cells
Mo et al., Toxicol In Vitro 2012
:
Our results suggest that UFPs and/or CSE caused activation of NADPH oxidase , resulting in ROS generation that led to activation of MAPKs through induced phosphorylation of p38 and ERK1/2 MAPKs and upregulation of Egr-1
Mai et al., J Pharmacol Sci 2012
(Glioma) :
These results suggest that CSE induces cell damage through intracellular Ca ( 2+ ) -dependent activation of PKCa and PKCe and subsequent NOX activation