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Smith et al., J Urol 2008
(Prostatic Neoplasms) :
Instead, PEDF activated in this order RhoA, nuclear factor kappaB and Stat3 Zheng et al., Invest Ophthalmol Vis Sci 2010
(Hyperglycemia) :
HG exposure caused hyperpolarization of Deltapsim and increased ROS generation in BRECs ; meanwhile, like H ( 2 ) O ( 2 ), it also induced the phosphorylation of JAK2/STAT3 and increased VEGF expression ; these changes were inhibited by PEDF