Sawhney et al., J Biol Chem 2004
(Colonic Neoplasms) :
Recently, we showed that autocrine transforming growth factor alpha ( TGFalpha ) controls the epidermal growth factor receptor (EGFR) mediated basal expression of integrin alpha2 , cell adhesion and motility in highly progressed HCT116 colon cancer cells
Yoon et al., Cancer Res 2006
(Breast Neoplasms...) :
In summary, we propose a novel mechanism for ErbB2 up-regulation and Ras activation in serum depleted breast cancer cells ; integrin alpha(6)beta ( 4 ) regulates the expression of ErbB2 and the subsequent phosphorylation of EGFR and activation of Ras
Chen et al., Mol Cell Biol 2010
:
Thus, integrin alpha1beta1 negatively regulates EGFR activation by positively controlling Cav-1 levels, and the ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1 dependent Cav-1 expression and consequent EGFR mediated ROS production