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EGF — MMP9

Text-mined interactions from Literome

Reddy et al., Int J Cancer 1999 (Breast Neoplasms...) : Blocking these signalling pathways significantly inhibited of EGF induced cell proliferation but only partially reduced in EGF induced MMP-9 secretion ... In contrast, when SKBR-3 cells were exposed to MEK inhibitor ( PD 98059 ) or MAPK inhibitors ( Apigenin or MAPK antisense phosphorothioate oligodeoxynucleotides ), EGF induced cell proliferation, MMP-9 induction and invasion through reconstituted basement membrane were significantly reduced
Sundareshan et al., Prostate 1999 (Adenocarcinoma...) : Induction of the MMP , matrilysin, by epidermal growth factor (EGF) was investigated in a human prostate cancer cell line
Huang et al., Br J Pharmacol 1999 (Neoplasm Metastasis) : 8. This study demonstrates that the inhibitory effects of Lu and Qu, and the stimulatory effects of EGF , on tumour cell proliferation, cellular protein phosphorylation, and MMP secretion may be mediated at least partly through EGFR
McCawley et al., Mol Pharmacol 2000 (MAP Kinase Signaling System) : Concentrations of forskolin that inhibit growth factor induced motility also eliminate EGF- or scatter factor/hepatocyte growth factor dependent induction of the 92-kDa gelatinase/MMP-9
Ellerbroek et al., Cancer Res 2001 (MAP Kinase Signaling System...) : Inhibition of PI3K and MAPK activity impairs EGF stimulated cell migration, in vitro invasion, and MMP-9 production ... EGF promotes pro-MMP-9 binding to the cell surface through a mechanism that is independent of extracellular enzyme concentration ... Interestingly, inhibition of PI3K activity abolishes EGF induced cell surface association of pro-MMP-9 , whereas inhibitors of MAPKs only partially block the response
Jarrousse et al., Int J Dermatol 2001 : Cytokine- and EGF induced upregulation of MMP-9 in the lower epithelial compartment of the human hair bulb is a major mechanism through which hair follicle involution, observed in alopecia, may occur
Huang et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : LHRH reduced both basal and EGF stimulated secretion of MMP-9 and MMP-2
Domeij et al., Eur J Oral Sci 2002 (MAP Kinase Signaling System) : In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF , was strongly reduced by the presence of the glucocorticoid dexamethasone
Price et al., Cell communication & adhesion 2002 (Breast Neoplasms...) : In response to EGF , T4-2 cells showed a 5-fold greater secretion of matrix metalloproteinase-9 (MMP-9) as compared to S-1 cells, and this increase was largely dependent on the activity of PI 3-kinase
Nutt et al., BJU Int 2003 (Urinary Bladder Neoplasms) : Matrix metalloproteinases ( MMPs ) in bladder cancer : the induction of MMP9 by epidermal growth factor and its detection in urine ... MMP9 was induced by EGF in the RT112 but not the RT4 bladder tumour cell line, whereas MMP2 production was unaffected by EGF ... EGF induces MMP9 but not MMP2 in bladder cells
Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Qiu et al., Reproduction 2004 (MAP Kinase Signaling System) : EGF induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways ... Whereas EGF up-regulates MMP-9 activity in a variety of cell types, there is no direct evidence for the stimulation of MMP-9 and tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) secretion by EGF in extravillous trophoblasts ... We showed for the first time that EGF activated both PI3K/Akt and MAPK/extracellular-signal regulated kinase ( ERK ) signalling in HTR8/SVneo, and increased both MMP-9 and TIMP-1 mRNAs and protein concentrations ... Our results suggest that the activation of both PI3K and MAPK pathways in extravillous trophoblasts is necessary for the up-regulation of MMP-9 and TIMP-1 expression by EGF
Vesey et al., Kidney Int 2005 (Calcium Signaling...) : These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation, the autocrine action of thrombin induced TGF-beta1 secretion, MMP activation, or EGF receptor transactivation
Yeudall et al., Oral Oncol 2005 (Carcinoma, Squamous Cell...) : However, EGF stimulated MMP-9 activity in invasive cells
Zhang et al., Pancreas 2006 (Neoplasm Invasiveness...) : Subsequently, the EGF induced MMP-9 and uPA expression and MMP-9 activity, as well as cell invasiveness, were also inhibited by these NF-kappaB inhibitors
Ahmed et al., Am J Physiol Cell Physiol 2006 (Cell Transformation, Neoplastic) : EGF increased cell motility, enhanced the activities of secreted pro-matrix metalloproteinase (MMP)-2 and -9 , and enhanced expression and activation of Erk and integrin linked kinase (ILK) ... EGF withdrawal resulted in a more epithelial morphology and reversal of the EGF induced activation of signaling pathways and pro-MMP activity ... The inhibitors caused suppression of EGF induced migration and pro-MMP-2/-9 activities but did not lead to any change in EGF induced mesenchymal morphology
Rothhut et al., Biochimie 2007 (Adenoma...) : Transient transfection and electrophoretic mobility shift assays ( EMSA ) were also performed to measure MMP-9 promoter activity, to identify multiple signaling pathways and to determine a proximal AP-1 binding site located between -79 to -73 base pairs upstream of the transcriptional start site that is involved in activation of MMP-9 by EGF ... Expression of FAK related non kinase (FRNK), a potent dominant negative inhibitor of FAK, reduced FAK auto-phosphorylation and inhibited EGF induced MMP-9 transcription and secretion leading to decreased cell invasion through Matrigel in in vitro Transwell assays
Cowden Dahl et al., Mol Cancer Res 2007 (Neoplasm Invasiveness...) : Additionally, inhibition of PEA3 expression via short interfering RNA reduced the EGF induction of MMP-9 and MMP-14 gene expression by 92 % and 50 %, respectively, and impaired EGF stimulated tumor cell invasion
Kuo et al., J Agric Food Chem 2009 (Bone Neoplasms...) : Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF induced MMP-9 expression ... 5GG inhibited the EGF induced cell invasiveness and MMP-9 expression in a dose- and time dependent manner by reducing the MMP-9 transcriptional activity
Kim et al., Cell Signal 2009 (Breast Neoplasms) : EGF induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line ... In this study, we investigated the novel function of the JAK3 inhibitor, WHI-P131, on EGF induced MMP-9 expression and the regulatory mechanism of EGF induced MMP-9 expression in SKBR3 cells ... EGF also induced the phosphorylation of EGFR, ERK, and STAT-3, and these effects were inhibited by the EGFR inhibitor, AG1478.To investigate the involvement of the STAT-3 pathway on EGF induced MMP-9 expression, we pretreatedSKBR3 cells with JAK1, JAK2, and JAK3 inhibitors prior to EGF treatment ... The results showed that the JAK3 inhibitor, WHI-P131, as well as JAK3 siRNA transfection, but not the JAK1 and JAK2 inhibitors, significantly decreased EGF induced MMP-9 expression ... Interestingly, EGF induced MMP-9 expression was decreased by Ad-STAT-3 overexpression in a dose dependent manner, while it was significantly increased by STAT-3 siRNA transfection ... On the other hand, EGF induced MMP-9 expression was decreased by the MEK1/2 inhibitor, UO126
Yu et al., Cytotechnology 2009 : Matrine significantly reduced the invasion, MMP-9/MMP-2 activation , Akt phosphorylation, nuclear factor kappaB p-65 expression and DNA binding activity, and mRNA levels of MMP-9, MMP-2, EGF and VEGFR1 in MDA-MB-231 cells
Zhao et al., Am J Pathol 2010 (Brain Neoplasms...) : An EGF receptor (EGFR) kinase inhibitor, a RasN17 dominant negative construct, MEK and PI3K inhibitors significantly blocked EGF/EGFR stimulated MMP-9 , cell invasion, and colony formation in U1242 MG cells, suggesting that MMP-9 is involved in EGFR/Ras/MEK and PI3K/AKT signaling pathway mediated cell invasion and anchorage independent growth in U1242 MG cells
Dilly et al., Mol Reprod Dev 2010 : Epidermal growth factor (EGF) induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells ... The aim of this in vitro study was to examine EGF mediated effects on cell motility, proliferation, and MMP-9 and TIMP-1 expression in cultured bovine trophoblast cells
Pan et al., Invest Ophthalmol Vis Sci 2011 : Hypertonicity induced EGF receptor (EGFR) transactivation was suppressed by preincubating HCECs with capsazepine, matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1, broad-spectrum MMP inhibitor GM 6001, heparin bound (HB)-EGF inhibitor CRM 197, or EGFR inhibitor AG 1478
Sen et al., Eur J Nutr 2011 (Breast Neoplasms) : Epigallocatechin-3-gallate ( EGCG ) downregulates EGF induced MMP-9 in breast cancer cells : involvement of integrin receptor a5ß1 in the process ... EGF induces MMP-9 activity and expression ; FAK, PI3 K, and ERK are mainly involved in the process ... EGCG downregulates EGF induced MMP-9 expression by inhibiting the involved regulatory kinases
Blair et al., Otol Neurotol 2011 (Neoplasm Invasiveness...) : EGF treatment moderately induced MMP9 , but is unlikely to account for the observed invasion
Hwang et al., Mol Nutr Food Res 2011 (Fibrosarcoma...) : Capsaicin inhibited the epidermal growth factor (EGF) induced activation of matrix metalloproteinase (MMP)-9 and MMP-2, and further inhibited cell invasion and migration ... Capsaicin decreased the EGF induced expression of MMP-9, MMP-2 , and MT1-MMP, but did not alter TIMP-1 and TIMP-2 levels ... Furthermore, the EGFR inhibitor inhibited EGF induced MMP-9 expression, as well as AP-1 activity and cell migration
Arima et al., Int J Oncol 1997 : Particularly, both the production of MMP-9 and DNA synthesis in TE10 were stimulated significantly by EGF
Zhang et al., Inflammation 2012 (Arthritis, Rheumatoid...) : IL-1ß or TNF-a increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes ; EGF stimulated expression of MMP-9 but not of MMP-2 ; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1ß or TNF-a ; rMMP-9, rMMP-2, or their inhibitors had no effect on the ( 3 ) H-TdR incorporation of synovial cells ... Genistein inhibited IL-1ß, TNF-a or EGF induced proliferation and MMP-9 expression in fibroblast-like synoviocytes of rheumatoid arthritis ; the proliferation of RA-FLS was mediated by Erk1/2 but not JNK activation, while JNK activation was involved in the signal transduction pathway leading to MMP-9 expression in rheumatoid synoviocytes
Kim et al., Cancer Lett 2012 (Breast Neoplasms) : We determined the effect of smad7 on EGF induced MMP-9 expression in SKBR3 breast cancer cells ... The expression of smad7 and MMP-9 was increased by EGF or TGF-ß1, respectively, and further increased by EGF and TGF-ß1 co-treatment ... In addition, EGF induced MMP-9 expression was inhibited by UO126 ( a MEK1/2 inhibitor ) or SIS3 ( a smad3 inhibitor ), but not by SP600125 ( a JNK inhibitor ) ... We also investigated the role of smad3 on EGF induced MMP-9 expression and showed that EGF induced MMP-9 expression was decreased by smad3 siRNA transfection, whereas EGF induced MMP-9 expression was further increased by smad3 over-expression, as expected
Tsai et al., Toxicon 2012 (MAP Kinase Signaling System...) : CTX III inhibited the EGF induced activation of matrix metalloproteinase-9 (MMP-9) , and further suppressed cell invasion and migration without obvious cellular cytotoxicity
Park et al., Br J Nutr 2013 (Neoplasm Invasiveness...) : Maslinic acid significantly ( P < 0·05 ) down-regulated both basal and EGF stimulated secretion of matrix metalloproteinase (MMP)-9 ( 25-67 % ), MMP-2 ( 50-86 % ), urokinase-type plasminogen activator ( uPA, about 100 % ), vascular endothelial growth factor ( VEGF, 98-100 % ) and tissue inhibitors of metalloproteinases ( TIMP ) -1, as well as expression of uPA receptor (uPAR), intercellular adhesion molecules ( 22-33 % ), vascular cell adhesion molecules ( 23-46 % ) and E-cadherin, whereas it increased TIMP-2 secretion
Hsieh et al., Toxicol In Vitro 2013 (Breast Neoplasms...) : Furthermore, the EGFR inhibitor AG1478 inhibited EGF induced MMP-9 expression, cell migration and invasion, as well as the activation of PI3K/Akt, suggesting that PI3K/Akt activation occur downstream of EGFR activation
Harvey et al., Development 1995 : Both LIF and EGF stimulated uPA and MMP-9 activity in blastocyst outgrowths after 3 days of culture ( day 7 )
Harvey et al., Hum Reprod 1995 : Recent experiments show that both LIF and EGF stimulate secretion of urokinase-type plasminogen activator ( uPA ) and gelatinase B/matrix metalloproteinase-9 (MMP-9) in day 7 mouse blastocyst outgrowths
Chen et al., Biochem Biophys Res Commun 1993 : Our results showed that EGF induced 92 kDa MMP-9 secretion was doubled in the ras transformed keratinocytes in comparison to the parent cells
Shimizu et al., Cancer Res 1996 (Carcinoma...) : Secretion of gelatinase B by LuM1 cells was augmented by tumor necrosis factor alpha, transforming growth factor beta1 ( TGF-beta1 ), interleukin 1beta, or epidermal growth factor , and specific neutralizing antibodies abolished the induced increases
Ueda et al., Int J Cancer 1997 (Carcinoma, Squamous Cell...) : We investigated the effects of epidermal growth factor (EGF) and transforming growth factor (TGF)-alpha on migration, invasion and matrix metalloproteinase ( MMP ) expression of uterine cervical-carcinoma SKG-IIIb cells, and whether these growth factors affect pyrimidine-nucleoside-phosphorylase ( PyNPase ) activity and 5'-deoxy-5-fluorouridine ( 5'-dFUrd ) sensitivity of tumor cells
Festuccia et al., Int J Cancer 1998 (Neoplasm Invasiveness...) : Similarly to EGF , bombesin stimulates secretion and activation of MMP-9 and TIMP-1 production
Watabe et al., Int J Cancer 1998 (Breast Neoplasms...) : Here, we have identified transcriptional requirements for the induction of uPA and 92 kDa type IV collagenase by epidermal growth factor (EGF) ... Reporter transfection assays revealed the activation of uPA and MMP-9 collagenase promoters by EGF and the requirement of each of the composite Ets and AP-1 transcription factor binding sites for an EGF response ... Most notably, transfections with the Ets-1 and Ets-2 expression vectors potentiated uPA and MMP-9 promoter activation in response to EGF
Charvat et al., Exp Dermatol 1998 : Cell migration and MMP-9 secretion are increased by epidermal growth factor in HaCaT-ras transfected cells
Ellerbroek et al., Int J Cancer 1998 (Neoplasm Invasiveness...) : EGF dependent stimulation of migration and induction of matrix metalloproteinase (MMP)-9 ( gelatinase B ) was observed in OVEA6 and OVCA 429 cells only ... Together, our findings indicate that multiple proteinases are important in ovarian cell invasion and implicate EGF induction of MMP-9 and migration as key components of more aggressive ligand induced invasion
Piedagnel et al., J Biol Chem 1999 : Matrix metalloproteinase 2 (MMP2) and MMP9 are produced by kidney collecting duct principal cells but are differentially regulated by SV40 large-T, arginine vasopressin, and epidermal growth factor ... Arginine vasopressin and epidermal growth factor , which exert opposite hydroosmotic effects in the collecting duct, also exhibited contrasted effects on MMP9 synthesis
McCawley et al., J Biol Chem 1999 : We have shown previously that although many receptor tyrosine kinase ligands are mitogens for keratinocytes, cell migration and induction of the 92-kilodalton gelatinase/matrix metalloproteinase (MMP)-9 are selectively regulated by the epidermal growth factor and scatter factor/hepatocyte growth factor receptors