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HDAC1 — SP1

Pathways - manually collected, often from reviews:

• BioCarta overview of telomerase protein component gene htert transcriptional regulation: SP1 → HDAC (HDAC1) (modification, collaborate)
• BioCarta overview of telomerase protein component gene htert transcriptional regulation: SP1 → SP1/HDAC complex (SP1-HDAC1) (modification, collaborate)
  
• BioCarta overview of telomerase protein component gene htert transcriptional regulation: HDAC (HDAC1) → SP1/HDAC complex (SP1-HDAC1) (modification, collaborate)
  
• BioCarta overview of telomerase protein component gene htert transcriptional regulation: SP1/HDAC complex (SP1-HDAC1) → TERT (transcription, inhibits)
• FastForward regulation: SP1 → HDAC1 (transcriptional regulation, unknown)
  Evidence: DNABINDING
• NCI Pathway Database E2F transcription factor network: E2F4/DP2/p107-p130/HDAC1 complex (E2F4-RBL2_RBL1-TFDP2-HDAC1) → SP1 (SP1) (transcription, inhibits) Takahashi et al., Genes Dev 2000, Johnson et al., Genes Dev 1994, Hsiao et al., Genes Dev 1994, Hurford et al., Genes Dev 1997, Ferreira et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC1 — SP1 (direct interaction, pull down) Lagger et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: HDAC1 — SP1 (direct interaction, two hybrid) Kang et al., Cell Physiol Biochem 2005*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Kang et al., Cell Physiol Biochem 2005*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Choi et al., Biochem Biophys Res Commun 2002*
• IRef Biogrid Interaction: HDAC1 — SP1 (direct interaction, pull down) Kang et al., Cell Physiol Biochem 2005*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Duan et al., Mol Cell Biol 2005*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Gan et al., J Biol Chem 2005*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Varshochi et al., J Biol Chem 2005*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Walker et al., Endocrinology 2001*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Plaisance et al., J Biol Chem 2005*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Shon et al., Virus Res 2009*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Mottet et al., Oncogene 2009*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Gao et al., Glia 2009*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Liu et al., Cancer Cell 2010*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Sekhavat et al., Biochem Cell Biol 2007*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Ammanamanchi et al., J Biol Chem 2004*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Doetzlhofer et al., Mol Cell Biol 1999*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Liu et al., Proc Natl Acad Sci U S A 2007*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Enya et al., J Leukoc Biol 2008*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Leclerc et al., Leukemia 2010*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Wong et al., J Biol Chem 2011*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Schnur et al., Biochim Biophys Acta 2007*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Singh et al., Oncogene 2002*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Di Padova et al., J Biol Chem 2003*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Zhang et al., J Biol Chem 2002*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Goto et al., J Bone Miner Res 2006*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Sun et al., J Biol Chem 2002*
• IRef Biogrid Interaction: HDAC1 — SP1 (physical association, affinity chromatography technology) Hung et al., Mol Cell Biol 2006*
• MIPS CORUM HCF-1 complex: HCF-1 complex complex (ASH2L-HCFC1-HDAC1-HDAC2-HSPA4-HSPA5-HSPA8-OGT-RBBP4-RBBP7-SAP30-SETD1A-SIN3A-SIN3B-SP1-SUDS3-WDR5-HSP90AA1-HSP90AB1) Wysocka et al., Genes Dev 2003
• IRef Corum Interaction: Complex of 20 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Singh et al., Oncogene 2002*
• IRef Hprd Interaction: HDAC1 — SP1 (in vivo) Singh et al., Oncogene 2002*, Alland et al., Mol Cell Biol 2002, Di Padova et al., J Biol Chem 2003*
• IRef Hprd Interaction: HDAC1 — SP1 (in vitro) Singh et al., Oncogene 2002*, Alland et al., Mol Cell Biol 2002, Di Padova et al., J Biol Chem 2003*
• IRef Intact Interaction: HDAC1 — SP1 (physical association, pull down) Di Padova et al., J Biol Chem 2003*
• IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
• IRef Ophid Interaction: HDAC1 — SP1 (aggregation, confirmational text mining) Di Padova et al., J Biol Chem 2003*
• IRef Ophid Interaction: HDAC1 — SP1 (aggregation, confirmational text mining) Alland et al., Mol Cell Biol 2002
• IRef Ophid Interaction: HDAC1 — SP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Doetzlhofer et al., Mol Cell Biol 1999 : Here we show that Sp1 can be a target for histone deacetylase 1 (HDAC1) mediated transcriptional repression
Sowa et al., Cancer Res 1999 : Sp3, but not Sp1 , mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor
Maehara et al., Biochem Biophys Res Commun 2002 : Our findings indicate that Mn-SOD gene expression is repressed by Sp1-HDAC1 complex
Ryu et al., Proc Natl Acad Sci U S A 2003 : Histone deacetylase (HDAC) inhibitors augment Sp1 acetylation, Sp1 DNA binding, and Sp1 dependent gene expression and confer resistance to oxidative stress induced death in vitro and in vivo
Meyers-Needham et al., EMBO Mol Med 2012 (Neoplasms) : Here we report that the CerS1 promoter was repressed by HDAC1 dependent inhibition of Sp1 recruitment to two specific GC-boxes spanning the -177 and -139 region
Yang et al., Epigenetics 2012 : CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1 ... These results indicate that TSA and SAHA could up-regulate CD1d expression in tumor cells through inhibition of HDAC1/2 and activation of Sp1
Kou et al., Carcinogenesis 2013 (Neoplasm Invasiveness...) : Histone deacetylase 1 was necessary for Sp1 to inhibit PTEN expression