Gene interactions and pathways from curated databases and text-mining

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FGF2 — ITGA5

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of ITGA5-ITGB1 → FGF2 (increases)
    Evidence: alpha2beta1 is upregulated by VEGF, alphaVbeta3 and alpha5beta1 are not, but instead are induced by bFGF, TNF and other angiogenic cytokines

Text-mined interactions from Literome

Grzeszkiewicz et al., J Biol Chem 2001 : By contrast, CYR61 enhancement of basic fibroblast growth factor induced DNA synthesis is mediated through integrin alpha(v)beta ( 3 ), a known receptor for CYR61 that mediates CYR61 dependent cell adhesion and chemotaxis in vascular endothelial cells
Fitzpatrick et al., Clin Chem 2006 : The fluorescence device detected expression of integrin alpha5 induced by basic fibroblast growth factor ( FGF-2 ) treatment in MCF-7 cells and that of Her-2/neu in SK-BR-3 cells compared with controls
Collo et al., J Cell Sci 1999 : We have investigated the effect of wound induced two-dimensional migration, basic fibroblast growth factor (bFGF) , transforming growth factor-beta1 ( TGF-beta1 ) and leukemia inhibitory factor (LIF) on expression of the alpha5beta1 integrin in endothelial cells