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IRF6 — TRAF6

Text-mined interactions from Literome

Lomaga et al., Genes Dev 1999 (Osteopetrosis) : TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
Hull et al., J Immunol 2002 : In contrast, LPS activation of p38 kinase is not inhibited by TRAF6-C
Huang et al., Nat Immunol 2004 : MEKK3 forms a complex with TRAF6 in response to IL-1 and lipopolysaccharide (LPS) but not CpG, and is required for IL-1R- and TLR4 induced IL-6 production
Lakshmanan et al., J Immunol 2007 : LPS stimulation led to the interaction of endogenous caspase-4 and TNFR associated factor 6 (TRAF6) via a TRAF6 binding motif ( PPESGE ), which we identified in caspase-4
Zhao et al., Am J Chin Med 2008 : The results indicate that LPS increased the expression of TLR4, MyD88, TRAF-6 , TRAM and TRIF, but had no influence on TLR3, while poly ( I:C ) up-regulated the expression of TLR3, MyD88, TRAM and TRIF
Shembade et al., EMBO J 2009 : RNF11 negatively regulated RIP1 and TRAF6 ubiquitination upon stimulation with TNF and LPS , respectively
Wan et al., J Biol Chem 2009 (MAP Kinase Signaling System) : Moreover, LPS stimulation induced an interaction of IRAK2 with TRAF6 , MKK3/6, and MK2, implicating a critical role for mitogen activated protein kinase signaling in LPS induced IRAK2 mediated post-transcriptional control
Liu et al., J Biol Chem 2012 : Finally, LPS increased binding of activated Tyr ( P ) ( 416 ) -SFK to GST-TRAF6, and preincubation of HMVEC-Ls with SFK-selective tyrosine kinase inhibitors, PP2 and SU6656, diminished TRAF6 binding to c-Src and Fyn ... The TRAF6 decoy peptide blocked both LPS induced SFK ubiquitination and TRAF6 phosphorylation
Jakus et al., J Nutr Biochem 2013 : Using RAW 264.7 macrophages, we determined the effect of resveratrol on LPS induced TRAF6 expression, ubiquitination as well as activation of mitogen activated protein ( MAP ) kinases and Akt in order to elucidate its involvement in TLR4 signaling ... We found that resveratrol diminishes the effect of LPS on TRAF6 ubiquitination and activation of JNK and p38 MAP kinases, while it has no effect on the activation of extracellular-signal regulated kinase ( ERK ) 1/2 ... Here, we provide the first evidence that resveratrol, by suppressing LPS induced TRAF6 expression and ubiquitination, attenuates the LPS induced TLR4-TRAF6, MAP kinase and Akt pathways that can be significant in its anti-inflammatory effects