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MAVS — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Seth et al., Cell 2005
(Respirovirus Infections) :
Conversely, overexpression of
MAVS induces the expression of IFN-beta through activation of
NF-kappaB and IRF 3, thus boosting antiviral immunity
Xu et al., Mol Cell 2005
:
Depletion of
VISA inhibits virus triggered and RIG-I mediated activation of IRF-3,
NF-kappaB , and the IFN-beta promoter, suggesting that VISA plays a central role in virus triggered TLR3 independent IFN-beta signaling
Meylan et al., Nature 2005
:
Overexpression of Cardif results in interferon-beta and
NF-kappaB promoter
activation , and knockdown of
Cardif by short interfering RNA inhibits RIG-I dependent antiviral responses
Ishii et al., Nat Immunol 2006
(Virus Diseases) :
IPS-1 , an adaptor molecule linking RIG-I and TBK1, was
involved in B-DNA induced activation of interferon-beta and
NF-kappaB
Sun et al., Immunity 2006
(Listeriosis...) :
By generating MAVS-deficient mice, here we show that loss of
MAVS abolished viral induction of interferons and
prevented the activation of
NFkappaB and IRF3 in multiple cell types, except plasmacytoid dendritic cells ( pDCs )
Sanada et al., J Biol Chem 2008
:
Forced expression of FLN29 inhibited the
IPS-1 dependent activation of both
NF-kappaB and IRF3
Yoshida et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
These data suggest that
IPS-1 requires TRAF6 and MEKK1 to activate
NF-kappaB and mitogen activated protein kinases that are critical for the optimal induction of type I interferons
Lauksund et al., Dev Comp Immunol 2009
(Birnaviridae Infections) :
Atlantic salmon
IPS-1 mediates induction of IFNa1 and activation of
NF-kappaB and localizes to mitochondria
Liu et al., Mol Biol Rep 2011
(Genetic Predisposition to Disease...) :
Virus induced signaling adapter (VISA) , an important adaptor protein linking both RIG-I and MDA-5 to downstream signaling events, may
mediates the activation of
NF kappaB and IRFs and the induction of type I IFN