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IL8 — ITIH4

Text-mined interactions from Literome

Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : The STAT1 inhibitor, fludarabine, prevented gp120 induced IL-6 and IL-8 secretion
Shah et al., Journal of neuroinflammation 2010 : HIV-1 gp120 mediated increases in IL-8 production in astrocytes are mediated through the NF-?B pathway and can be silenced by gp120-specific siRNA ... In this study, we sought to address whether HIV-1gp120 could affect IL-8 expression in astrocytes and whether the NF-?B pathway is involved in this phenomenon ... Gp120 increased IL-8 expression both at mRNA and protein levels by 7.1 ± 1.04 and 2.41 ± 0.35 fold at 6 and 48 hours post-transfection, respectively ... We have also shown that the NF-?B pathway is involved in gp120 mediated IL-8 overexpression as IKK-2 and IKKß inhibitors inhibited IL-8 expression by 63.5 % and 57.5 %, respectively at the mRNA level, and by 67.3 % and 58.6 % at the protein level
Shah et al., PloS one 2012 (MAP Kinase Signaling System) : Our results clearly suggest that gp120 and MA affect IL-6 but not IL-8 in a synergistic manner and this synergy was mediated by PI3K/Akt and NF-?B pathways
Taoufik et al., Blood 1997 : Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes : an indirect interleukin-10 mediated effect